Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Inflammation. 2013 Feb;36(1):164-8. doi: 10.1007/s10753-012-9531-9.
Different studies have shown the regulatory effects of vitamin D(3) on the immune system and bone metabolism. Regarding the effects of vitamin D on immune cells and the importance of cytokines on bone metabolism, we assessed the association between serum levels of interleukin (IL)-6, IL-10, IL-12, IL-17 and IFN-γ cytokines and bone metabolism markers (Ca, P, PTH, ALP) in female students with vitamin D deficiency compared with control group. A total of 100 subjects with 25-hydroxy vitamin D(3) (25-(OH) D(3)) deficiency were selected as case and 100 subjects with sufficient 25-hydroxy vitamin D(3) (25-(OH) D(3)) were selected as the control group. The serum levels of IL-6, IL-10, IL-12, IL-17 and IFN-γ were measured by ELISA method. Ionized Ca, PTH, P, ALP levels were also determined in all participants. The results showed a statistically significant positive correlation between the levels of ALP with IFN-γ, PTH with IL-17 and a significant negative correlation between P with IL-10 in vitamin D deficient group. The results suggest that IL-17, IFN-γ and IL-10 are important mediators of bone metabolism and vitamin D affect bone metabolism, at least in part, through immune system. In addition, not only vitamin D affect bone metabolism but also modulates immune responses.
不同的研究表明维生素 D（3）对免疫系统和骨骼代谢具有调节作用。关于维生素 D 对免疫细胞的影响以及细胞因子对骨骼代谢的重要性，我们评估了维生素 D 缺乏的女学生血清中白细胞介素（IL）-6、IL-10、IL-12、IL-17 和 IFN-γ 细胞因子与骨代谢标志物（Ca、P、PTH、ALP）之间的相关性，与对照组进行比较。共选择了 100 名血清 25-羟维生素 D（3）（25-（OH）D（3））缺乏的受试者作为病例组，选择 100 名血清 25-羟维生素 D（3）（25-（OH）D（3））充足的受试者作为对照组。通过 ELISA 法测量血清中 IL-6、IL-10、IL-12、IL-17 和 IFN-γ 的水平。所有参与者的离子 Ca、PTH、P、ALP 水平也都进行了测定。结果表明，在维生素 D 缺乏组中，ALP 与 IFN-γ、PTH 与 IL-17 之间存在显著的正相关，而 P 与 IL-10 之间存在显著的负相关。结果表明，IL-17、IFN-γ 和 IL-10 是骨骼代谢的重要调节因子，维生素 D 至少部分通过免疫系统影响骨骼代谢。此外，不仅维生素 D 影响骨骼代谢，还调节免疫反应。
