Gruber A, Grillner L, Norder H, Magnius L, Björkholm M
Division of Medicine, Karolinska Hospital, Stockholm, Sweden.
Ann Hematol. 1993 Mar;66(3):157-9. doi: 10.1007/BF01697628.
Aplastic anemia (AA) is a rare complication of viral hepatitis affecting mainly children or young adults. Most reported cases have been associated with community-acquired non-A, non-B hepatitis, but hepatitis A and B have also been implicated in a few patients. We report on a 43-year-old woman with severe AA, in association with acute hepatitis C virus (HCV) infection, diagnosed by detection of HCV RNA by the polymerase chain reaction technique. Her AA was successfully treated with anti-thymocyte globulin and cyclosporin A. The hepatitis C progressed to chronic disease but, despite a follow-up time of 2 years, the patient still has no detectable anti-HCV antibodies, as evaluated with a second-generation anti-HCV assay.
再生障碍性贫血（AA）是病毒性肝炎的一种罕见并发症，主要影响儿童或年轻人。大多数报道的病例与社区获得性非甲非乙型肝炎有关，但甲型和乙型肝炎也累及少数患者。我们报告了一名43岁患有严重再生障碍性贫血的女性，她同时伴有急性丙型肝炎病毒（HCV）感染，通过聚合酶链反应技术检测HCV RNA得以确诊。她的再生障碍性贫血通过抗胸腺细胞球蛋白和环孢素A成功治愈。丙型肝炎进展为慢性病，但尽管随访了2年，用第二代抗HCV检测方法评估，该患者仍未检测到抗HCV抗体。
