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本文引用的文献

1
Prolonged gonadotropin stimulation is associated with decreased ART success.促性腺激素刺激时间延长与辅助生殖技术（ART）成功率降低有关。
J Assist Reprod Genet. 2010 Dec;27(12):711-7. doi: 10.1007/s10815-010-9476-6. Epub 2010 Sep 7.
2
Comparison of follicular fluid and serum cytokine concentrations in women undergoing assisted reproductive treatment with GnRH agonist long and antagonist protocols.比较 GnRH 激动剂长方案和拮抗剂方案行辅助生殖治疗的女性的卵泡液和血清细胞因子浓度。
Gynecol Endocrinol. 2010 Mar;26(3):181-6. doi: 10.1080/09513590903215557.
3
Replete vitamin D stores predict reproductive success following in vitro fertilization.维生素 D 储备充足可预测体外受精后的生殖成功。
Fertil Steril. 2010 Sep;94(4):1314-1319. doi: 10.1016/j.fertnstert.2009.05.019. Epub 2009 Jul 8.
4
Roles for transforming growth factor beta superfamily proteins in early folliculogenesis.转化生长因子β超家族蛋白在卵泡早期发生中的作用。
Semin Reprod Med. 2009 Jan;27(1):14-23. doi: 10.1055/s-0028-1108006. Epub 2009 Feb 5.
5
Serum levels of soluble vascular cell adhesion molecule-1, tumor necrosis factor-alpha, and interleukin-6 in in vitro fertilization cycles.
Fertil Steril. 2009 May;91(5 Suppl):2012-9. doi: 10.1016/j.fertnstert.2008.04.039. Epub 2008 Sep 7.
6
Immune-like mechanisms in ovulation.排卵中的免疫样机制。
Trends Endocrinol Metab. 2008 Aug;19(6):191-6. doi: 10.1016/j.tem.2008.03.001. Epub 2008 Apr 11.
7
The levels of steroid hormones and cytokines in individual follicles are not associated with the fertilization outcome after intracytoplasmic sperm injection.单个卵泡中类固醇激素和细胞因子的水平与卵胞浆内单精子注射后的受精结果无关。
Fertil Steril. 2008 Jul;90(1):60-4. doi: 10.1016/j.fertnstert.2007.05.054. Epub 2007 Nov 5.
8
Differential expression of follicular fluid cytokines: relationship to subsequent pregnancy in IVF cycles.卵泡液细胞因子的差异表达：与体外受精周期中后续妊娠的关系。
Reprod Biomed Online. 2007 Sep;15(3):321-5. doi: 10.1016/s1472-6483(10)60346-x.
9
Novel follicular fluid factors influencing oocyte developmental potential in IVF: a review.体外受精中影响卵母细胞发育潜能的新型卵泡液因子：综述
Reprod Biomed Online. 2006 Apr;12(4):500-6. doi: 10.1016/s1472-6483(10)62005-6.
10
Reduced expression of interleukin-11 and interleukin-6 in the periimplantation endometrium of excessive ovarian responders during in vitro fertilization treatment.体外受精治疗期间，卵巢反应过度者种植窗期子宫内膜中白细胞介素-11和白细胞介素-6表达降低。
J Clin Endocrinol Metab. 2006 Aug;91(8):3181-8. doi: 10.1210/jc.2006-0180. Epub 2006 May 16.

在接受试管婴儿治疗的患者中，卵泡液中白细胞介素 6 水平较低与临床妊娠率增加相关。

Low follicular fluid IL-6 levels in IVF patients are associated with increased likelihood of clinical pregnancy.

机构信息

Ankara State Research and Training Hospital, Ankara, Turkey.

出版信息

J Assist Reprod Genet. 2011 Mar;28(3):245-51. doi: 10.1007/s10815-010-9502-8. Epub 2010 Nov 3.

DOI:10.1007/s10815-010-9502-8
PMID:21046223
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3082657/
Abstract

PURPOSE

Relationships between follicular fluid levels of IL-6 with ovarian response and clinical pregnancy were evaluated in IVF-ET cycles.

METHODS

Follicular fluid was collected from ovarian follicles ≥ 14 mm, pooled for each patient, and IL-6 levels were assessed using ELISA (n = 68). Relationships between IL-6 levels and IVF cycle parameters were assessed using nonparametric tests, and between IL-6 levels and clinical pregnancy using multivariable logistic regression analyses.

RESULTS

Significant positive correlations were observed between IL-6 with age (p = 0.035), and IL-6 with estradiol on the day of hCG (p = 0.011). On adjusted analyses, IVF cycles in patients with IL-6 levels <4.0 pg/ml (median value for the group) demonstrated an almost 4-fold increase in likelihood for clinical pregnancy (p = 0.045).

CONCLUSIONS

Lower follicular fluid IL-6 levels in IVF patients are associated with increased likelihood of clinical pregnancy. We hypothesize that endometrial receptivity is a likely target for any deleterious influences of elevated IL-6 levels.

摘要

目的

评估 IVF-ET 周期中卵泡液中白细胞介素-6（IL-6）水平与卵巢反应和临床妊娠的关系。

方法

收集≥14mm 的卵巢卵泡中的卵泡液，对每个患者进行汇集，并使用 ELISA 法评估 IL-6 水平（n=68）。使用非参数检验评估 IL-6 水平与 IVF 周期参数之间的关系，使用多变量逻辑回归分析评估 IL-6 水平与临床妊娠之间的关系。

结果

IL-6 与年龄呈显著正相关（p=0.035），与 hCG 日的雌二醇呈显著正相关（p=0.011）。在调整分析中，IL-6 水平<4.0pg/ml（该组的中位数）的 IVF 周期患者临床妊娠的可能性几乎增加了 4 倍（p=0.045）。

结论

IVF 患者卵泡液中较低的 IL-6 水平与临床妊娠的可能性增加相关。我们假设子宫内膜容受性是升高的 IL-6 水平产生任何有害影响的可能靶点。