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Intrafollicular interleukin-8, interleukin-12, and adrenomedullin are the promising prognostic markers of oocyte and embryo quality in women with endometriosis.卵泡内白细胞介素-8、白细胞介素-12和肾上腺髓质素是子宫内膜异位症女性卵母细胞和胚胎质量有前景的预后标志物。
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Follicular Fluid Growth Factors and Interleukin Profiling as Potential Predictors of IVF Outcomes.卵泡液生长因子和白细胞介素分析作为体外受精结局的潜在预测指标
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本文引用的文献

1
Risk markers of reproductive loss in women with hyperandrogenism.高雄激素血症女性生殖损失的风险标志物。
Wiad Lek. 2018;71(8):1550-1553.
2
Follicle development as an orchestrated signaling network in a 3D organoid.卵泡发育作为三维类器官中的一个精心编排的信号网络。
J Biol Eng. 2019 Jan 9;13:2. doi: 10.1186/s13036-018-0134-3. eCollection 2019.
3
Effect of single-dose ibuprofen on follicular fluid levels of interleukins in poor responders undergoing in vitro fertilization.单剂量布洛芬对体外受精低反应者卵泡液中白细胞介素水平的影响。
Syst Biol Reprod Med. 2019 Feb;65(1):48-53. doi: 10.1080/19396368.2018.1557761. Epub 2018 Dec 20.
4
IL-5 in follicular fluid as a negative predictor of the intracytoplasmic sperm injection outcome.卵泡液中的白介素 5 作为卵胞浆内单精子注射结局的负预测因子。
Cytokine. 2019 Jan;113:265-271. doi: 10.1016/j.cyto.2018.07.016. Epub 2018 Jul 30.
5
Antiangiogenic cytokines as potential new therapeutic targets for resveratrol in diabetic retinopathy.抗血管生成细胞因子作为白藜芦醇治疗糖尿病视网膜病变潜在的新治疗靶点。
Drug Des Devel Ther. 2018 Jul 3;12:1985-1996. doi: 10.2147/DDDT.S156941. eCollection 2018.
6
Interleukin-6: designing specific therapeutics for a complex cytokine.白细胞介素 6：为复杂细胞因子设计特异性治疗药物。
Nat Rev Drug Discov. 2018 Jun;17(6):395-412. doi: 10.1038/nrd.2018.45. Epub 2018 May 4.
7
Early Endometriosis in Females Is Directed by Immune-Mediated Estrogen Receptor α and IL-6 Cross-Talk.女性早期子宫内膜异位症由免疫介导的雌激素受体α和白细胞介素-6相互作用所调控。
Endocrinology. 2018 Jan 1;159(1):103-118. doi: 10.1210/en.2017-00562.
8
Gonadotrophin stimulation in IVF alters the immune cell profile in follicular fluid and the cytokine concentrations in follicular fluid and serum.在试管婴儿中使用促性腺激素刺激会改变卵泡液中的免疫细胞谱以及卵泡液和血清中的细胞因子浓度。
Hum Reprod. 2017 Apr 1;32(4):820-831. doi: 10.1093/humrep/dex005.
9
Intrafollicular inflammatory cytokines but not steroid hormone concentrations are increased in naturally matured follicles of women with proven endometriosis.在经证实患有子宫内膜异位症的女性自然成熟卵泡中，卵泡内炎性细胞因子浓度升高，但甾体激素浓度未升高。
J Assist Reprod Genet. 2017 Mar;34(3):357-364. doi: 10.1007/s10815-016-0865-3. Epub 2017 Jan 10.
10
Intrafollicular interleukin-8, interleukin-12, and adrenomedullin are the promising prognostic markers of oocyte and embryo quality in women with endometriosis.卵泡内白细胞介素-8、白细胞介素-12和肾上腺髓质素是子宫内膜异位症女性卵母细胞和胚胎质量有前景的预后标志物。
J Assist Reprod Genet. 2016 Oct;33(10):1363-1372. doi: 10.1007/s10815-016-0782-5. Epub 2016 Aug 5.

卵泡液中的白细胞介素 6 可减少胚胎碎片形成，提高临床妊娠率。

Interleukin 6 in follicular fluid reduces embryo fragmentation and improves the clinical pregnancy rate.

机构信息

Reproduction Center, The Second Affiliated Hospital of Kunming Medical University, Dianmian Road 374, Kunming, 650101, Yunnan Province, China.

出版信息

J Assist Reprod Genet. 2020 May;37(5):1171-1176. doi: 10.1007/s10815-020-01737-2. Epub 2020 Mar 18.

DOI:10.1007/s10815-020-01737-2
PMID:32189182
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7244683/
Abstract

PURPOSE

The aim of this study was to evaluate the role of interleukin 6 in embryo development in the in vitro fertilization cycles.

METHODS

This was a retrospective cohort study. One hundred and three women undergoing in vitro fertilization and embryo transfer due to a tubal factor were included in the study. The follicular fluid IL-6 levels on oocyte retrieval day from each patient were determined by ELISA. The relationships between follicular fluid IL-6 levels and IVF cycle parameters were investigated.

RESULTS

The levels of follicular fluid IL-6 were not affected by the use of drugs for superovulation or by estrogen. In addition, follicular fluid IL-6 levels did not affect the number of oocytes retrieved or the MII oocyte rate. High levels of follicular fluid IL-6 correlated with a significant increase in the rates of clinical pregnancy. Follicular fluid IL-6 levels did not affect the cell number or the blastomere symmetry of day 3 embryos, but it did significantly reduce the embryo fragmentation rate.

CONCLUSIONS

High levels of follicular fluid IL-6 improved the rates of clinical pregnancy and reduce embryo fragmentation.

摘要

目的

本研究旨在评估白细胞介素 6 在体外受精周期中胚胎发育中的作用。

方法

这是一项回顾性队列研究。本研究纳入了 103 名因输卵管因素接受体外受精和胚胎移植的女性。通过 ELISA 法测定每位患者取卵日卵泡液中白细胞介素 6 的水平。研究了卵泡液 IL-6 水平与 IVF 周期参数之间的关系。

结果

卵泡液 IL-6 水平不受超排卵药物和雌激素的影响。此外，卵泡液 IL-6 水平并不影响获卵数或 MII 卵率。高卵泡液 IL-6 水平与临床妊娠率显著增加相关。卵泡液 IL-6 水平并不影响第 3 天胚胎的细胞数或卵裂球对称性，但显著降低胚胎碎片率。

结论

高卵泡液 IL-6 水平可提高临床妊娠率，降低胚胎碎片率。