卵泡液中的白细胞介素 6 可减少胚胎碎片形成，提高临床妊娠率。
Interleukin 6 in follicular fluid reduces embryo fragmentation and improves the clinical pregnancy rate.
机构信息
Reproduction Center, The Second Affiliated Hospital of Kunming Medical University, Dianmian Road 374, Kunming, 650101, Yunnan Province, China.
出版信息
J Assist Reprod Genet. 2020 May;37(5):1171-1176. doi: 10.1007/s10815-020-01737-2. Epub 2020 Mar 18.
Abstract
PURPOSE
The aim of this study was to evaluate the role of interleukin 6 in embryo development in the in vitro fertilization cycles.
METHODS
This was a retrospective cohort study. One hundred and three women undergoing in vitro fertilization and embryo transfer due to a tubal factor were included in the study. The follicular fluid IL-6 levels on oocyte retrieval day from each patient were determined by ELISA. The relationships between follicular fluid IL-6 levels and IVF cycle parameters were investigated.
RESULTS
The levels of follicular fluid IL-6 were not affected by the use of drugs for superovulation or by estrogen. In addition, follicular fluid IL-6 levels did not affect the number of oocytes retrieved or the MII oocyte rate. High levels of follicular fluid IL-6 correlated with a significant increase in the rates of clinical pregnancy. Follicular fluid IL-6 levels did not affect the cell number or the blastomere symmetry of day 3 embryos, but it did significantly reduce the embryo fragmentation rate.
CONCLUSIONS
High levels of follicular fluid IL-6 improved the rates of clinical pregnancy and reduce embryo fragmentation.
摘要
目的
本研究旨在评估白细胞介素 6 在体外受精周期中胚胎发育中的作用。
方法
这是一项回顾性队列研究。本研究纳入了 103 名因输卵管因素接受体外受精和胚胎移植的女性。通过 ELISA 法测定每位患者取卵日卵泡液中白细胞介素 6 的水平。研究了卵泡液 IL-6 水平与 IVF 周期参数之间的关系。
结果
卵泡液 IL-6 水平不受超排卵药物和雌激素的影响。此外，卵泡液 IL-6 水平并不影响获卵数或 MII 卵率。高卵泡液 IL-6 水平与临床妊娠率显著增加相关。卵泡液 IL-6 水平并不影响第 3 天胚胎的细胞数或卵裂球对称性，但显著降低胚胎碎片率。
结论
高卵泡液 IL-6 水平可提高临床妊娠率，降低胚胎碎片率。
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