Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas, PO Box 6111, Campinas, SP 13083-970, Brazil.
Qual Life Res. 2011 Feb;20(1):133-8. doi: 10.1007/s11136-010-9726-1. Epub 2010 Nov 3.
Besides the typical organic aspects of Chagas disease, the patients need to face physical, psychological, social and economic difficulties, which can compromise their quality of life. Consequently they may develop feelings of sadness, grief and loss, and depressive symptoms.
This study assessed the quality of life and depressive symptoms in 110 Chagas disease patients using WHOQOL-BREF for measuring the quality of life; also it was used Beck Depression Inventory (BDI) for depressive symptom evaluation.
Among all patients, 51% were women; 42.5% considered their quality of life as positive and 40.9% presented depressive symptoms. Chagas disease clinical form distribution was: cardiac 49.09%, indeterminate 26.36%, digestive 12.73%, and mixed 11.82%. There was no significant difference comparing the depressive symptom intensity on gender, age and marital status, although there was a significant difference comparing depressive symptoms in indeterminate clinical form patients with others. All domains of WHOQOL-BREF showed significant correlation coefficients (Pearson).
At digestive form it was reported minor scores in the quality of life domains and greater ones on depressive symptom levels. There was a negative correlation between BDI and WHOQOL-BREF, suggesting that, among Chagas disease patients, the higher is the quality of life the lower is the intensity of depressive symptoms.
除了恰加斯病的典型器质性方面，患者还需要面对身体、心理、社会和经济困难，这可能会影响他们的生活质量。因此，他们可能会感到悲伤、悲痛和失落，并出现抑郁症状。
本研究使用世界卫生组织生活质量简表（WHOQOL-BREF）评估了 110 例恰加斯病患者的生活质量和抑郁症状；同时使用贝克抑郁量表（BDI）评估了抑郁症状。
在所有患者中，51%为女性；42.5%认为自己的生活质量为阳性，40.9%存在抑郁症状。恰加斯病的临床形式分布为：心脏 49.09%，不确定 26.36%，消化 12.73%，混合 11.82%。在性别、年龄和婚姻状况方面，抑郁症状的强度没有显著差异，但在不确定临床形式的患者与其他患者之间存在显著差异。WHOQOL-BREF 的所有领域均显示出显著的相关系数（皮尔逊）。
在消化形式中，生活质量领域的得分较低，抑郁症状水平较高。BDI 与 WHOQOL-BREF 呈负相关，这表明在恰加斯病患者中，生活质量越高，抑郁症状的强度越低。
