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tramtrack基因编码一种果蝇指蛋白,该蛋白与ftz转录调控区域相互作用,并呈现出一种新的胚胎表达模式。

The tramtrack gene encodes a Drosophila finger protein that interacts with the ftz transcriptional regulatory region and shows a novel embryonic expression pattern.

作者信息

Harrison S D, Travers A A

机构信息

MRC Laboratory of Molecular Biology, Cambridge UK.

出版信息

EMBO J. 1990 Jan;9(1):207-16. doi: 10.1002/j.1460-2075.1990.tb08097.x.

DOI:10.1002/j.1460-2075.1990.tb08097.x
PMID:2104801
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC551648/
Abstract

We have identified a Drosophila zinc-finger protein, which binds to a number of sites in the transcriptional control regions of the pair-rule gene fushi-tarazu (ftz). The expression pattern of the mRNA that encodes this protein is essentially complementary to that of ftz both prior to blastoderm formation and during germband extension. We propose that the protein may function by repressing inappropriate segmentation gene transcription during embryogenesis. The gene encoding this ftz promoter-binding protein has been named tramtrack (ttk).

摘要

我们鉴定出一种果蝇锌指蛋白,它能与成对规则基因“腹节缺失”(ftz)转录控制区的多个位点结合。在囊胚形成之前以及胚带延伸期间,编码这种蛋白的mRNA的表达模式与ftz的表达模式基本互补。我们推测,该蛋白可能通过在胚胎发育过程中抑制不适当的体节基因转录来发挥作用。编码这种ftz启动子结合蛋白的基因已被命名为“轨道交错”(ttk)。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d851/551648/86643ab54220/emboj00228-0206-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d851/551648/86643ab54220/emboj00228-0206-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d851/551648/86643ab54220/emboj00228-0206-a.jpg

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