Umeda Yukihiro, Morikawa Miwa, Anzai Masaki, Sumida Yasuyuki, Kadowaki Maiko, Ameshima Shingo, Ishizaki Takeshi
Department of Respiratory Medicine, Faculty of Medical Sciences, University of Fukui, Fukui.
Intern Med. 2010;49(21):2333-6. doi: 10.2169/internalmedicine.49.3890. Epub 2010 Nov 1.
We report a case of acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) after pandemic influenza (H1N1) vaccination. A 57-year-old man, who had been diagnosed with IPF in September 2008, was admitted to our hospital in December 2009 because of aggravation of dyspnea and fever two days after H1N1 vaccination. Chest computed tomography showed diffuse bilateral ground-glass opacities superimposed on preceding reticular opacities. We diagnosed AE-IPF. Corticosteroid and cyclophosphamide were effective. Although the efficacy of influenza vaccination in patients with chronic lung diseases is well established, physicians should keep in mind that influenza vaccination has the potential to cause AE-IPF.
我们报告一例甲型H1N1流感大流行疫苗接种后特发性肺纤维化急性加重（AE-IPF）的病例。一名57岁男性，于2008年9月被诊断为IPF，2009年12月因接种甲型H1N1流感疫苗两天后出现呼吸困难加重和发热而入住我院。胸部计算机断层扫描显示双肺弥漫性磨玻璃影叠加在先前的网状阴影上。我们诊断为AE-IPF。皮质类固醇和环磷酰胺治疗有效。虽然流感疫苗在慢性肺病患者中的疗效已得到充分证实，但医生应牢记流感疫苗有导致AE-IPF的可能性。
