Gaffrey Michael S, Luby Joan L, Repovš Grega, Belden Andy C, Botteron Kelly N, Luking Katherine R, Barch Deanna M
Departments of Psychiatry, Washington University, St Louis, Missouri, USA.
Neuroreport. 2010 Dec 29;21(18):1182-8. doi: 10.1097/WNR.0b013e32834127eb.
The subgenual anterior cingulate cortex (sgACC) presents altered functional connections with other regions of the brain in individuals with depression. However, the developmental nature of this phenomenon remains largely unexplored. Functional connections of the sgACC were examined in 36 school age children, 17 with a history of preschool onset major depressive disorder (PO-MDD). The sgACC exhibited increased connections with cognitive control regions in healthy children and increased connections with thalamic and parietal regions in the PO-MDD group. A significant correlation between dysregulated emotional behavior and connectivity of the sgACC and dorsal medial prefrontal cortex was also found. These findings demonstrate that atypical sgACC functional connections are evident as early as school age in children with a history of PO-MDD and suggest an association with a very early episode of depression.
膝下前扣带回皮质（sgACC）在抑郁症患者中与大脑其他区域的功能连接发生了改变。然而，这一现象的发育本质在很大程度上仍未得到探索。对36名学龄儿童的sgACC功能连接进行了检查，其中17名有学龄前起病的重度抑郁症（PO-MDD）病史。在健康儿童中，sgACC与认知控制区域的连接增加，而在PO-MDD组中，sgACC与丘脑和顶叶区域的连接增加。还发现情绪行为失调与sgACC和背内侧前额叶皮质的连接性之间存在显著相关性。这些发现表明，有PO-MDD病史的儿童在学龄期就已出现非典型的sgACC功能连接，提示其与非常早期的抑郁发作有关。
