Parreira Samara Lamounier Santana, Resende Maria Bernadete Dutra, Zanoteli Edmar, Carvalho Mary Souza, Marie Suely Kazue, Reed Umbertina Conti
Department of Neurology, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
Arq Neuropsiquiatr. 2010 Oct;68(5):683-8. doi: 10.1590/s0004-282x2010000500002.
To compare muscle strength (MS) and motor function in patients with Duchenne muscular dystrophy (DMD) receiving steroids for different times against the natural evolution of DMD described by Scott et al.
90 patients with DMD (aged 5- 12 years), receiving steroids for one to seven years, were evaluated by Medical Research Council Scale (MRC) and Hammersmith motor ability score. The relation between MS and motor abilities measurement from our data and Scott's ones were ascertained statistically.
The relation between patient's age and Hammersmith scores revealed decrease of 0.76 point per year for age against decrease of 2.23 points on Scott's study. The relation between MRC scale and patient's age showed decrease of 0.80 point per year of age against decrease of 3.65 points on Scott's study.
In patients with DMD aged five to 12 years the progression of the disease is delayed by steroids and the motor function is less reduced than muscular strength.
将接受不同时长类固醇治疗的杜氏肌营养不良症（DMD）患者的肌肉力量（MS）和运动功能，与Scott等人描述的DMD自然病程进行比较。
采用医学研究委员会量表（MRC）和哈默史密斯运动能力评分，对90例年龄在5至12岁、接受类固醇治疗1至7年的DMD患者进行评估。对我们的数据与Scott的数据中MS和运动能力测量值之间的关系进行统计学分析。
患者年龄与哈默史密斯评分之间的关系显示，年龄每增加一岁，评分下降0.76分，而在Scott的研究中下降2.23分。MRC量表与患者年龄之间的关系显示，年龄每增加一岁，评分下降0.80分，而在Scott的研究中下降3.65分。
在5至12岁的DMD患者中，类固醇可延缓疾病进展，且运动功能的降低程度小于肌肉力量。
