Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi.
Lancet Infect Dis. 2010 Dec;10(12):886-92. doi: 10.1016/S1473-3099(10)70201-2. Epub 2010 Nov 1.
Reliable and relevant research can help to improve tuberculosis control worldwide. In recent years, various organisations have assessed research needs and proposed priorities for tuberculosis. We summarise existing priority statements and assess the rigour of the methods used to generate them. We found 33 documents that specifically outline priorities in tuberculosis research. The top priority areas were drug development (28 articles), diagnosis and diagnostic tests (27), epidemiology (20), health services research (16), basic research (13), and vaccine development and use (13). The most focused questions were on the treatment and prevention of multidrug-resistant tuberculosis in people co-infected with HIV. Methods used to identify these priorities were varied. Improvements can be made to ensure the process is more rigorous and transparent, and to use existing research or systematic reviews more often. WHO, Stop TB Partnership, and other organisations could adopt an incremental process of priority development, building on the existing knowledge base.
可靠且相关的研究有助于改善全球结核病控制。近年来，各种组织已经评估了结核病的研究需求，并提出了研究重点。我们总结了现有的重点声明，并评估了用于生成这些声明的方法的严谨性。我们发现了 33 份专门概述结核病研究重点的文件。优先重点领域是药物开发（28 篇文章）、诊断和诊断测试（27）、流行病学（20）、卫生服务研究（16）、基础研究（13）和疫苗开发和使用（13）。最关注的问题是针对艾滋病毒合并感染人群中耐多药结核病的治疗和预防。用于确定这些重点的方法多种多样。可以改进这些方法，以确保该过程更加严谨和透明，并更频繁地使用现有研究或系统评价。世卫组织、遏制结核病伙伴关系和其他组织可以在现有知识库的基础上，采用渐进式重点开发过程。
