在停用高剂量地西泮和奥沙西泮联合用药期间，地西泮及其代谢产物在人乳中的排泄情况。
Excretion of diazepam and its metabolites in human milk during withdrawal from combination high dose diazepam and oxazepam.
作者信息
Dusci L J, Good S M, Hall R W, Ilett K F
机构信息
Combined Unit in Clinical Pharmacology and Toxicology, State Health Laboratory Services, Perth, Western Australia.
出版信息
Br J Clin Pharmacol. 1990 Jan;29(1):123-6. doi: 10.1111/j.1365-2125.1990.tb03612.x.
Abstract
The excretion of diazepam, N-desmethyldiazepam, temazepam and oxazepam in breast milk was studied during withdrawal of a 22-year-old patient from combined high dose diazepam and oxazepam therapy. Concentrations of these benzodiazepines in plasma from both the woman and her nursing infant (1 year old) were also documented. Diazepam, N-desmethyldiazepam, temazepam and oxazepam were found in the maternal plasma and milk with mean milk: plasma ratios of 0.2, 0.13, 0.14 and 0.10 respectively. It was calculated on a mg kg-1 basis that the infant received some 4.7% of the maternal dose. Diazepam could not be detected in the infant's plasma, but low levels of N-desmethyldiazepam (20 and 21 micrograms l-1), temazepam (7 micrograms l-1) and oxazepam (7.5 and 9.6 micrograms l-1) were present. The infant showed no overt physical or mental symptoms of benzodiazepine intoxication.
摘要
在一名22岁患者停用大剂量地西泮和奥沙西泮联合治疗期间，研究了母乳中地西泮、N-去甲基地西泮、替马西泮和奥沙西泮的排泄情况。同时记录了该女性及其1岁哺乳期婴儿血浆中这些苯二氮䓬类药物的浓度。在母体血浆和乳汁中均检测到地西泮、N-去甲基地西泮、替马西泮和奥沙西泮，平均乳汁与血浆浓度比分别为0.2、0.13、0.14和0.10。以毫克每千克体重计算，婴儿摄入的药物约为母体剂量的4.7%。在婴儿血浆中未检测到地西泮，但存在低水平的N-去甲基地西泮（20和21微克/升）、替马西泮（7微克/升）和奥沙西泮（7.5和9.6微克/升）。婴儿未表现出苯二氮䓬类药物中毒的明显身体或精神症状。
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