Carter D A
Neuropeptide Laboratory, National University of Singapore.
Biochem Biophys Res Commun. 1990 Jan 30;166(2):589-94. doi: 10.1016/0006-291x(90)90849-i.
In the rat pineal gland c-fos is transiently and markedly induced after the onset of darkness. The induction is abolished following removal of the superior cervical ganglion and reproduced in ganglionectomized animals by treatment with the adrenergic agonist isoproterenol. These findings show for the first time that induction of c-fos forms an integral part of physiological changes in cellular activity. Expression of the c-fos gene may be functionally linked to the nocturnal changes in pineal indole metabolism.
在大鼠松果体中，c-fos在黑暗开始后会被短暂且显著地诱导。切除颈上神经节后这种诱导作用消失，而在去神经节动物中通过用肾上腺素能激动剂异丙肾上腺素处理可使其重现。这些发现首次表明c-fos的诱导是细胞活动生理变化的一个组成部分。c-fos基因的表达可能在功能上与松果体吲哚代谢的夜间变化相关。
