School of Kinesiology and Recreation, Illinois State University, Normal, IL 61790-5120, USA.
J Investig Med. 2011 Jan;59(1):27-31. doi: 10.231/JIM.0b013e318200151a.
Many medical concerns associated with obesity are due to chronic inflammation, but factors underlying the development or maintenance of obesity-associated inflammation remain unclear. This study investigated how age, sex, and ethnicity may modify the interplay of subclinical inflammation and obesity in nationally representative contexts.
Using National Health and Nutrition Examination Survey data from 1999 to 2008, we assessed the role of these demographic factors on immunological markers of subclinical inflammation (such as total white blood cell counts, white blood cell subpopulation counts, and C-reactive protein [CRP] levels) in both obese and nonobese individuals. Approximately 9756 individuals were included in the analysis after removing individuals with confounding conditions.
The CRP levels, total white blood cell count, and white blood cell subpopulation counts increased with increasing body mass index (BMI). After controlling for BMI, female subjects had greater levels of most inflammatory markers compared with male subjects. After controlling for age, sex, and ethnicity, the following inflammatory markers significantly increased with increasing BMI: CRP and white blood cell, lymphocyte, monocyte, and neutrophil counts. Basophil and eosinophil counts also increased with increasing BMI but not significantly.
Factors, such as age, sex, and ethnicity, may modify the influence of obesity on subclinical inflammation at the population level.
许多与肥胖相关的医学问题都源于慢性炎症，但肥胖相关炎症的发生或持续存在的因素仍不清楚。本研究旨在探讨年龄、性别和种族等因素如何在具有代表性的人群中调节亚临床炎症与肥胖之间的相互作用。
利用 1999 年至 2008 年全国健康与营养调查的数据，我们评估了这些人口统计学因素在肥胖和非肥胖个体中对亚临床炎症的免疫标志物（如总白细胞计数、白细胞亚群计数和 C 反应蛋白 [CRP] 水平）的作用。在去除有混杂因素的个体后，约有 9756 人纳入分析。
随着体重指数（BMI）的增加，CRP 水平、总白细胞计数和白细胞亚群计数也随之增加。在控制 BMI 后，女性受试者的大多数炎症标志物水平均高于男性受试者。在控制年龄、性别和种族后，随着 BMI 的增加，以下炎症标志物显著增加：CRP 和白细胞、淋巴细胞、单核细胞和中性粒细胞计数。嗜碱性粒细胞和嗜酸性粒细胞计数也随 BMI 的增加而增加，但无统计学意义。
年龄、性别和种族等因素可能会在人群水平上调节肥胖对亚临床炎症的影响。
