Department of Pharmacology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Eur Rev Med Pharmacol Sci. 2010 Sep;14(9):765-9.
Pistacia lentiscus has traditionally been used in the treatment of many diseases. Its resin was investigated for its mineral contents, anti-inflammatory and antioxidant activities in rats.
Inhibition of carrageenan induced edema was used to evaluate anti-inflammatory activity. Fe2+ chelating ability, 1,1-diphenyl-2-picryl hydrazyl radical (DPPH) and nitric oxide scavenging activities were used to evaluate antioxidant activities and mineral contents were determined by atomic absorption spectroscopy. Gallic acid content was determined by HPLC.
Resin produced statistically significant inhibition of edema at all doses when compared to the control groups. A 100% inhibition of inflammation was observed at 800 mg/kg i.p. Resin exhibit no toxicity up to 3 g/kg body weights i.p. in mice. Weak DPPH and nitric oxide scavenging activities were observed but showed good Fe2+ chelating ability (IC50 = 162 microg ml(-1)). The amount of elements was decreased in the order: Cu > Fe, Zn > Mn > Ni, Cd. Gallic acid content was 0.1 mg/g resin.
These experimental data support the use of Pistacia lentiscus resin as an antiinflammatory and antioxidant agent.
乳香黄连木在传统上被用于治疗多种疾病。本研究旨在探讨其树脂的矿物含量、对大鼠的抗炎和抗氧化活性。
采用角叉菜胶诱导的大鼠足肿胀模型来评价其抗炎活性。通过测定铁离子螯合能力、1,1-二苯基-2-苦基肼基自由基（DPPH）和一氧化氮清除活性来评价抗氧化活性，并采用原子吸收光谱法测定矿物含量。采用高效液相色谱法测定没食子酸含量。
与对照组相比，树脂在所有剂量下均能显著抑制水肿。腹腔注射 800 mg/kg 时，炎症抑制率达到 100%。腹腔注射剂量高达 3 g/kg 时，树脂对小鼠无毒性。树脂表现出较弱的 DPPH 和一氧化氮清除活性，但具有良好的铁离子螯合能力（IC50 = 162 微克/毫升）。元素含量按以下顺序降低：Cu > Fe > Zn > Mn > Ni > Cd。树脂中没食子酸的含量为 0.1 毫克/克。
这些实验数据支持乳香黄连木树脂作为一种抗炎和抗氧化剂的使用。
