Ham Seoyoon, Lee Young In, Jang Yujin, Lee Sang Gu, Suk Jangmi, Jung Inhee, Park Jae Hyun, Lee Ju Hee
Department of Dermatology & Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.
Scar Laser and Plastic Surgery Center, Yonsei Cancer Hospital, Seoul, Korea.
Yonsei Med J. 2025 May;66(5):310-320. doi: 10.3349/ymj.2024.0100.
Hair disorders, which are often attributed to conditions associated with a shortened anagen growth phase, oxidative stress, and hormonal dysregulation, especially during aging, have profound psychological implications. Currently, only minoxidil has been approved as a topical hair growth solution; thus, alternative therapies for treating hair loss and promoting hair health are urgently needed. Herein, we aimed to develop and assess a novel method to promote hair growth and health using mastic (Pistacia lentiscus) gum and peppermint (Mentha piperita L.) extracts.
After determining the optimal ratio of mastic gum and peppermint extracts, we performed in vitro and in vivo experiments to verify the efficacy of the 7:3 mastic gum-peppermint mixture (MP73; FHH-MG) for enhancing hair growth and health.
Mastic gum significantly promoted cell proliferation and demonstrated synergistic benefits when combined with peppermint extract. In vitro, FHH-MG increased human dermal follicle papilla cell proliferation and demonstrated anti-inflammatory and antioxidant effects. In vivo, treatment with FHH-MG dose-dependently enhanced hair growth and gloss and increased the expression of vascular endothelial growth factor, epidermal growth factor, β-catenin, and insulin-like growth factor-1 in C57BL/6 mice compared to the negative control.
The novel mixture exhibited hair growth-promoting effects in C57BL/6 mice; thus, FHH-MG may serve as a botanical alternative for hair growth and health promotion.
毛发疾病常归因于与生长期缩短、氧化应激和激素失调相关的状况，尤其是在衰老过程中，具有深远的心理影响。目前，仅有米诺地尔被批准作为局部生发溶液；因此，迫切需要治疗脱发和促进毛发健康的替代疗法。在此，我们旨在开发并评估一种使用乳香（乳香黄连木）胶和薄荷（薄荷属）提取物促进毛发生长和健康的新方法。
在确定乳香胶和薄荷提取物的最佳比例后，我们进行了体外和体内实验，以验证7:3乳香胶 - 薄荷混合物（MP73；FHH - MG）促进毛发生长和健康的功效。
乳香胶显著促进细胞增殖，与薄荷提取物联合使用时显示出协同益处。在体外，FHH - MG增加了人毛囊乳头细胞增殖，并表现出抗炎和抗氧化作用。在体内，与阴性对照相比，FHH - MG处理剂量依赖性地增强了C57BL / 6小鼠的毛发生长和光泽，并增加了血管内皮生长因子、表皮生长因子、β - 连环蛋白和胰岛素样生长因子 - 1的表达。
这种新型混合物在C57BL / 6小鼠中表现出促进毛发生长的作用；因此，FHH - MG可作为促进毛发生长和健康的植物性替代物。
