Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka, 812-8581, Japan.
Cytotechnology. 2011 Mar;63(2):119-31. doi: 10.1007/s10616-010-9317-6. Epub 2010 Nov 10.
Electrolyzed reduced water, which is capable of scavenging reactive oxygen species, is attracting recent attention because it has shown improved efficacy against several types of diseases including diabetes mellitus. Alloxan produces reactive oxygen species and causes type 1 diabetes mellitus in experimental animals by irreversible oxidative damage to insulin-producing β-cells. Here, we showed that electrolyzed reduced water prevented alloxan-induced DNA fragmentation and the production of cells in sub-G1 phase in HIT-T15 pancreatic β-cells. Blood glucose levels in alloxan-induced type 1 diabetes model mice were also significantly suppressed by feeding the mice with electrolyzed reduced water. These results suggest that electrolyzed reduced water can prevent apoptosis of pancreatic β-cells and the development of symptoms in type 1 diabetes model mice by alleviating the alloxan-derived generation of reactive oxygen species.
电解还原水能够清除活性氧，由于其在改善多种疾病（包括糖尿病）方面的疗效而受到关注。在实验动物中，丙烯醛通过对胰岛素分泌β细胞的不可逆氧化损伤产生活性氧，导致 1 型糖尿病。在这里，我们表明电解还原水可防止丙烯醛诱导的 HIT-T15 胰腺β细胞中的 DNA 片段化和亚 G1 期细胞的产生。通过给实验用 1 型糖尿病模型小鼠喂食电解还原水，也显著抑制了其血糖水平。这些结果表明，电解还原水可通过减轻丙烯醛衍生的活性氧的产生来防止胰腺β细胞凋亡和 1 型糖尿病模型小鼠症状的发展。
