Department of Obstetrics and Gynecology, Södertälje Hospital, Södertälje, Sweden.
Fertil Steril. 2011 Mar 1;95(3):1188-91. doi: 10.1016/j.fertnstert.2010.09.062. Epub 2010 Nov 10.
In a prospective, randomized clinical study 77 women were assigned randomly to receive sequential hormone therapy with either conventional oral conjugated equine estrogens (0.625 mg) with the addition on 14 of the 28 days of oral medroxyprogesterone acetate (5 mg) or natural E(2) gel (1.5 mg) with oral micronized P (200 mg) on 14 of the 28 days of each cycle. Because oral conjugated equine estrogens-medroxyprogesterone acetate induced a highly significant increase in breast cell proliferation in contrast to percutaneous E(2)-oral P with a difference between therapies approaching significance, the former therapy has a marked impact on the breast whereas natural percutaneous E(2)-oral micronized P has not.
在一项前瞻性、随机临床试验中，77 名女性被随机分配接受序贯激素治疗，分别接受常规口服结合雌激素（0.625mg）加 14 天口服醋酸甲羟孕酮（5mg）或每个周期的 14 天接受天然 E2 凝胶（1.5mg）加口服微粒化 P（200mg）。由于口服结合雌激素-醋酸甲羟孕酮与经皮 E2-口服 P 相比，显著增加了乳腺细胞增殖，两种治疗方法之间的差异接近显著水平，前者治疗对乳房有明显影响，而天然经皮 E2-口服微粒化 P 则没有。
