Department of Chemistry, Faculty of Food Science and Biotechnology, University of Life Sciences in Lublin, Akademicka 15 Street, 20-950 Lublin, Poland.
Nutrients. 2019 Jul 20;11(7):1660. doi: 10.3390/nu11071660.
Scientific advancements in recent years have shed new light on the relationship between diet and human health. Nutrients play an important role in the prevention of many civilization diseases, such as osteoporosis, type II diabetes, hypercholesterolemia, and cardiovascular diseases. The biological activity of natural plant components allows their use in the treatment of various diseases, especially civilization diseases, to be speculated. Special attention is paid to phenolic compounds that have numerous health-promoting properties. Isoflavones, phenolic compounds, are commonly found in legumes, especially in soybeans. Their structural similarity to 17-β-estradiol (E2), the main female sex hormone, allows them to induce estrogenic and antiestrogenic effects by binding to estrogen receptors, and their consumption has been associated with a decreased risk of hormone-related cancers. In addition, numerous epidemiological studies and related meta-analyses suggest that soy consumption may be associated with a lower incidence of certain diseases. However, there are some doubts about the potential effects on health, such as the effectiveness of cardiovascular risk reduction or breast cancer-promoting properties. The purpose of this review is to present the current knowledge on the potential effects of soy isoflavone consumption with regard to civilization diseases.
近年来，科学的进步为饮食与人类健康之间的关系提供了新的认识。营养物质在预防许多文明病方面起着重要作用，如骨质疏松症、Ⅱ型糖尿病、高胆固醇血症和心血管疾病。天然植物成分的生物活性使得它们可以被用于治疗各种疾病，特别是文明病，这一点受到了推测。特别关注具有多种促进健康特性的酚类化合物。异黄酮是一种常见的酚类化合物，存在于豆类中，特别是大豆中。其与 17-β-雌二醇（E2）的结构相似，E2 是主要的女性性激素，使其能够通过与雌激素受体结合而产生雌激素和抗雌激素作用，并且其消费与降低与激素相关的癌症风险有关。此外，许多流行病学研究和相关的荟萃分析表明，大豆的消费可能与某些疾病的发病率较低有关。然而，对于健康的潜在影响仍存在一些疑问，例如对心血管疾病风险降低的有效性或促进乳腺癌的特性。本综述的目的是介绍关于消费大豆异黄酮与文明病相关的潜在影响的现有知识。
