Kimula Y
Am J Surg Pathol. 1978 Sep;2(3):253-64. doi: 10.1097/00000478-197809000-00002.
Twenty-five cases of solitary nodular adenocarcinoma of the human lung were studied histochemically and ultrastructurally and their morphological characteristics were compared to the cells observed in the control lungs. Adenocarcinoma cells of the human lung may be classified into following four types: Type A--cells resembling the bronchial goblet cell; Type B--cells resembling the mucous cell of the bronchial gland; Type C--cells resembling the type II alveolar lining cell; and Type D--cells resembling the nonciliated bronchiolar cell. Twenty-one cases belonging to Type D (84%) and two cases to Type B (8%), and one case each to Types A (4%) and C (4%). For the histogenesis of adenocarcinoma of the human lung, nonciliated bronchiolar epithelium may be the most important. A comparison of 10 cases of bronchiolo-alveolar carcinoma with 15 cases of ordinary (acinar and papillary) adenocarcinoma revealed no clear differences either histochemically or ultrastructurally.
对25例人肺孤立性结节性腺癌进行了组织化学和超微结构研究，并将其形态学特征与对照肺中观察到的细胞进行了比较。人肺腺癌细胞可分为以下四种类型：A型——类似支气管杯状细胞的细胞；B型——类似支气管腺黏液细胞的细胞；C型——类似II型肺泡内衬细胞的细胞；D型——类似无纤毛细支气管细胞的细胞。21例属于D型（84%），2例属于B型（8%），A型（4%）和C型（各1例，4%）。对于人肺腺癌的组织发生，无纤毛细支气管上皮可能是最重要的。对10例细支气管肺泡癌和15例普通（腺泡状和乳头状）腺癌进行比较，结果显示在组织化学或超微结构方面均无明显差异。
