Mount Sinai Heart, Mount Sinai Medical Center, New York, NY 10029, USA.
J Nucl Cardiol. 2010 Dec;17(6):1009-14. doi: 10.1007/s12350-010-9215-5. Epub 2010 Nov 12.
Cardiac SPECT imaging needs to become shorter and use lower radiation doses to compete with other available noninvasive imaging modalities. Recently introduced cadmium zinc telluride (CZT) SPECT cameras have the potential to achieve both goals, but clinical experience is so far limited.
Images of all patients undergoing a stress MPI over a 4-month period using a CZT camera (Discovery NM 530c) were reviewed. Patients were divided into three groups based on imaging protocols: low-dose stress-only, high-dose stress-only, and standard dose rest-stress. Low-dose stress-only patients were matched by gender, stressor, and BMI to high-dose stress-only and rest-stress subjects. Stress image quality was graded on a four-point scale by readers blinded to the imaging protocol. Demographics, tracer dose, stress imaging time, and total counts were recorded.
Of 717 patients imaged, the mean age was 64.0 years, 50.5% were female, 58.9% underwent exercise stress, and the average BMI was 27.9 kg/m(2). A total of 103 low-dose stress-only patients were matched to controls. Imaging for 5 minutes in low-dose stress-only patients and for 3 minutes in high-dose stress-only and rest-stress patients, resulted in a similar number of total counts. This produced similar image quality in the three groups with a 57% isotope dose reduction in the low-dose stress-only compared to the high-dose stress-only group.
New SPECT CZT camera technology allows significantly reduced radiation exposure and acquisition time without loss of image quality.
心脏 SPECT 成像需要缩短时间并降低辐射剂量，才能与其他可用的无创成像方式竞争。最近推出的碲锌镉（CZT）SPECT 相机有可能实现这两个目标，但目前临床经验有限。
回顾了在 4 个月期间使用 CZT 相机（Discovery NM 530c）进行的所有应激 MPI 患者的图像。根据成像方案将患者分为三组：低剂量应激仅、高剂量应激仅和标准剂量静息-应激。低剂量应激仅患者通过性别、应激源和 BMI 与高剂量应激仅和静息-应激患者匹配。读者对成像方案不知情，对压力图像质量进行了四级评分。记录了人口统计学、示踪剂剂量、应激成像时间和总计数。
在 717 名接受成像的患者中，平均年龄为 64.0 岁，50.5%为女性，58.9%接受运动应激，平均 BMI 为 27.9kg/m2。共有 103 名低剂量应激仅患者与对照组匹配。低剂量应激仅患者的成像时间为 5 分钟，高剂量应激仅和静息-应激患者的成像时间为 3 分钟，导致总计数相似。这使得三组的图像质量相似，与高剂量应激仅组相比，低剂量应激仅组的同位素剂量减少了 57%。
新型 SPECT CZT 相机技术允许显著降低辐射暴露和采集时间，而不会降低图像质量。
