Shim Hyun Joon, Jung Hoon, Park Dong Choon, Lee Jong Ha, Yeo Seung Geun
Department of Otolaryngology, College of Medicine, EulJi University, Seoul, Korea.
Acta Otolaryngol. 2011 Feb;131(2):210-5. doi: 10.3109/00016489.2010.520167. Epub 2010 Nov 11.
Ramsay Hunt syndrome (RHS) with multiple involvement of cranial nerves is more severe and intractable than RHS without such involvement.
Typically, RHS involves VII and VIII nerves and unilaterally, and RHS accompanied by multiple cranial neuropathy is very rare. We describe 11 patients who developed RHS with multicranial nerve involvement and we analyzed their clinical characteristics and compared them with those of patients with RHS not accompanied by multiple cranial neuropathy.
During the period 1995-2009, we treated 339 patients with RHS; of these, 11 patients had concurrent multiple cranial neuropathy. We assessed the clinical characteristics of RHS patients with and without multiple cranial neuropathy.
The mean age of the 11 patients with multiple cranial neuropathy (6 men, 5 women) was 49.2 ± 19.4 years, although 7 were aged 50 years or older. Eight patients had right-sided and three had left-sided facial paralysis. The initial degree of facial paralysis was House-Brackmann (HB) grade IV in four patients (36.4%) and HB grade V in seven (63.6%). Six patients showed improvement in symptoms, whereas five (45.6%) showed no improvement. The recovery rates from facial paralysis in patients with and without multiple cranial neuropathy were 54.5% and 82.9%, respectively, and the complete recovery rates were 27.3% and 67.7%, respectively.
累及多条颅神经的拉姆齐·亨特综合征（RHS）比未累及多条颅神经的RHS更严重且更难治疗。
典型的RHS通常累及VII和VIII神经且为单侧受累，伴有多发性颅神经病变的RHS非常罕见。我们描述了11例发生RHS且伴有多颅神经受累的患者，并分析了他们的临床特征，同时将其与未伴有多发性颅神经病变的RHS患者进行比较。
在1995年至2009年期间，我们治疗了339例RHS患者；其中，11例同时患有多发性颅神经病变。我们评估了伴有和不伴有多发性颅神经病变的RHS患者的临床特征。
11例伴有多发性颅神经病变的患者（6例男性，5例女性）平均年龄为49.2±19.4岁，其中7例年龄在50岁及以上。8例患者为右侧面瘫，3例为左侧面瘫。4例患者（36.4%）面神经麻痹的初始程度为House-Brackmann（HB）IV级，7例（63.6%）为HB V级。6例患者症状有所改善，而5例（45.6%）无改善。伴有和不伴有多发性颅神经病变的患者面神经麻痹的恢复率分别为54.5%和82.9%，完全恢复率分别为27.3%和67.7%。
