Biostatistics and Epidemiology, College of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
Community Dent Oral Epidemiol. 2011 Apr;39(2):186-92. doi: 10.1111/j.1600-0528.2010.00586.x. Epub 2010 Nov 10.
Associations between dental conditions and overall health have been previously reported. Investigators have also shown significant inverse relationships between serum albumin (a general health status marker) and root caries. This relationship was explored among a study population of Gullah African Americans (who have a considerably lower level of non-African genetic admixture when compared to other African American populations) with type-2 diabetes (T2DM) and self-reported history of normal kidney function (N=280).
Root caries indices were defined as total decayed and/or filled root surfaces. The coronal caries index [total decayed, missing, and/or filled coronal surfaces (DMFS)], level of glycemic control, total number of teeth, and other covariates were also evaluated. Logistic regression models were used to evaluate the associations between these factors and hypoalbuminemia (serum albumin concentrations <4 g/dl).
Serum albumin concentrations ranged 2.4-4.5 g/dl (mean=3.8, SD=0.3), with 70.4% exhibiting hypoalbuminemia. Root caries totals ranged 0-38 (mean=1.3, SD=4.5) surfaces decayed/filled, while total teeth ranged 1-28 (mean=19.4, SD=6.2). DMFS totals ranged 2-116 (mean=55.2, SD=28.0). We failed to detect significant associations for root caries; however, the final multivariable logistic regression models showed significant associations between hypoalbuminemia and total teeth [odds ratio (OR)=0.93, P=0.01], poor glycemic control (OR=2.49, P<0.01), elevated C-reactive protein (OR=1.57, P<0.01), glomerular filtration rates ≥60 (OR=0.31, P=0.03), and age (OR=0.97, P=0.03).
Previously reported inverse relationships between serum albumin and root caries were not evident in our study population. We propose that these null findings are because of the considerably lower level of root caries as well as other differing characteristics (including oral health status, the chronic presence of T2DM, and predominantly younger age) within our study population compared to these previously assessed groups.
先前已有研究报告表明，牙齿状况与整体健康之间存在关联。研究人员还发现，血清白蛋白（一般健康状况标志物）与根面龋之间存在显著的负相关关系。本研究在 280 名患有 2 型糖尿病（T2DM）且自我报告肾功能正常的 Gullah 非裔美国人（与其他非裔美国人人群相比，其非非洲遗传混合程度要低得多）中探讨了这一关系。
根面龋指数定义为总龋坏和/或已填充的根面数。还评估了冠部龋病指数[总龋坏、缺失和/或已填充的冠部表面（DMFS）]、血糖控制水平、总牙数和其他协变量。使用逻辑回归模型评估这些因素与低白蛋白血症（血清白蛋白浓度<4g/dl）之间的关联。
血清白蛋白浓度范围为 2.4-4.5g/dl（平均值=3.8，标准差=0.3），其中 70.4%的人存在低白蛋白血症。根面龋总数范围为 0-38（平均值=1.3，标准差=4.5）个已龋坏/已填充的面，而总牙数范围为 1-28（平均值=19.4，标准差=6.2）个。DMFS 总数范围为 2-116（平均值=55.2，标准差=28.0）。我们未能检测到根面龋之间存在显著关联；然而，最终的多变量逻辑回归模型显示，低白蛋白血症与总牙数[比值比（OR）=0.93，P=0.01]、血糖控制不佳（OR=2.49，P<0.01）、C 反应蛋白升高（OR=1.57，P<0.01）、肾小球滤过率≥60（OR=0.31，P=0.03）和年龄（OR=0.97，P=0.03）之间存在显著关联。
先前报告的血清白蛋白与根面龋之间的负相关关系在我们的研究人群中并不明显。我们提出，这些无效发现是因为我们研究人群的根面龋发生率较低，以及其他不同的特征（包括口腔健康状况、慢性 2 型糖尿病的存在以及以年轻人群为主）与先前评估的这些人群不同。
