Biegel Eva, Schmidt Silke, González José M, Müller Volker
Molecular Microbiology and Bioenergetics, Institute of Molecular Biosciences, Johann Wolfgang Goethe University Frankfurt/Main, Frankfurt, Germany.
Cell Mol Life Sci. 2011 Feb;68(4):613-34. doi: 10.1007/s00018-010-0555-8. Epub 2010 Nov 12.
Microbes have a fascinating repertoire of bioenergetic enzymes and a huge variety of electron transport chains to cope with very different environmental conditions, such as different oxygen concentrations, different electron acceptors, pH and salinity. However, all these electron transport chains cover the redox span from NADH + H(+) as the most negative donor to oxygen/H(2)O as the most positive acceptor or increments thereof. The redox range more negative than -320 mV has been largely ignored. Here, we have summarized the recent data that unraveled a novel ion-motive electron transport chain, the Rnf complex, that energetically couples the cellular ferredoxin to the pyridine nucleotide pool. The energetics of the complex and its biochemistry, as well as its evolution and cellular function in different microbes, is discussed.
微生物拥有一系列迷人的生物能量酶和各种各样的电子传递链，以应对截然不同的环境条件，如不同的氧气浓度、不同的电子受体、pH值和盐度。然而，所有这些电子传递链覆盖的氧化还原跨度都是从作为最负供体的NADH + H(+)到作为最正受体的氧气/H(2)O或其增量。比-320 mV更负的氧化还原范围在很大程度上被忽视了。在这里，我们总结了最近的数据，这些数据揭示了一种新型的离子动力电子传递链——Rnf复合物，它在能量上把细胞型铁氧化还原蛋白与吡啶核苷酸库联系起来。本文讨论了该复合物的能量学、生物化学，以及它在不同微生物中的进化和细胞功能。
