World J Gastroenterol. 2010 Nov 14;16(42):5272-9. doi: 10.3748/wjg.v16.i42.5272.
The intestinal mucosa is responsible for the absorption of nutrients from the lumen and for the separation of the potentially toxic luminal content (external environment) from the host (internal environment). Disruption of this delicate balance at the mucosal interface is the basis for numerous (intestinal) diseases. Experimental animal studies have shown that gut wall integrity loss is involved in the development of various inflammatory syndromes, including post-operative or post-traumatic systemic inflammatory response syndrome, sepsis, and multiple organ failure. Assessment of gut wall integrity in clinical practice is still a challenge, as it is difficult to evaluate the condition of the gut non-invasively with currently available diagnostic tools. Moreover, non-invasive, rapid diagnostic means to assess intestinal condition are needed to evaluate the effects of treatment of intestinal disorders. This review provides a survey of non-invasive tests and newly identified markers that can be used to assess gut wall integrity.
肠黏膜负责从肠腔中吸收营养物质，并将潜在有毒的肠腔内容物（外环境）与宿主（内环境）分隔开。这种黏膜界面上微妙平衡的破坏是许多（肠道）疾病的基础。实验动物研究表明，肠壁完整性的丧失与各种炎症综合征的发展有关，包括术后或创伤后全身炎症反应综合征、脓毒症和多器官衰竭。在临床实践中评估肠壁完整性仍然是一个挑战，因为目前可用的诊断工具很难对肠道状况进行非侵入性评估。此外，还需要非侵入性、快速的诊断手段来评估肠道疾病的治疗效果。本文综述了可用于评估肠壁完整性的非侵入性检测方法和新发现的标志物。
