Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.
Ann Epidemiol. 2010 Dec;20(12):955-7. doi: 10.1016/j.annepidem.2010.08.011.
We previously proposed an oxidative balance score (OBS) and illustrated its practical application by using data from previously completed case-control studies of two neoplasms - sporadic colorectal adenoma and prostate cancer. In the present study we extend our analysis by substituting questionnaire-based measures with systemic biomarkers of pro- and anti-oxidant exposures.
Low, medium and high pro-oxidant exposures, and high, medium and low antioxidant exposures were assigned 0, 1 and 2 points, respectively and individual points for all exposures were then summed to calculate the overall score. Case and controls were compared using logistic regression analysis after adjusting for covariates.
When OBS was treated as a continuous variable the adjusted odds ratios and 95% confidence intervals (CI) for each additional score point were the same: 0.90 (95% CI: 0.83-0.97) for each study. When the OBS was divided into three approximately equal intervals, a comparison of the lowest to highest category showed similar adjusted ORs (95% CIs) of 0.34 (0.13-0.88) and 0.34 (0.14-0.86) for colorectal adenoma and prostate cancer, respectively.
Our analyses provide support for the stated hypothesis that combined measures of pro- and anti-oxidant exposures may be associated with oxidative stress-related conditions.
我们之前提出了氧化平衡评分（OBS），并通过使用来自两个肿瘤——散发性结直肠腺瘤和前列腺癌的已完成病例对照研究的数据，说明了其实际应用。在本研究中，我们通过用系统生物标志物替代基于问卷的抗氧化剂和氧化剂暴露测量方法，扩展了我们的分析。
低、中、高氧化剂暴露和高、中、低抗氧化剂暴露分别被赋予 0、1 和 2 分，然后将所有暴露的个体分数相加以计算总分。在调整协变量后，使用逻辑回归分析比较病例和对照组。
当 OBS 被视为连续变量时，每个额外分数点的调整后比值比和 95%置信区间（CI）相同：对于每个研究，0.90（95%CI：0.83-0.97）。当 OBS 分为三个大致相等的区间时，最低到最高类别的比较显示出类似的调整后 OR（95%CI），结直肠腺瘤为 0.34（0.13-0.88），前列腺癌为 0.34（0.14-0.86）。
我们的分析支持这样一种假设，即氧化剂和抗氧化剂暴露的综合测量可能与氧化应激相关的疾病有关。
