Department of Gastroenterology, The First Hospital of Jilin University, Changchun, China.
Norman Bethune Health Science Center, Jilin University, Changchun, China.
Front Endocrinol (Lausanne). 2024 Apr 30;15:1397512. doi: 10.3389/fendo.2024.1397512. eCollection 2024.
The Oxidative Balance Score (OBS) is commonly used to assess oxidative stress and provides a comprehensive evaluation of dietary and lifestyle-related exposures. However, there is limited research on the association between OBS and colorectal cancer (CRC), its subsites, and complications. The objective of this study was to assess the relationship between OBS and the risk of CRC, its subsites, and common complications in a large prospective cohort study.
We included data from 175,808 participants in the UK Biobank data sample repository from 2006 to 2010. We evaluated OBS using a scoring system based on 22 dietary and lifestyle factors. Multiple adjustments, including multivariate Cox proportional hazard regression, gender stratification, subgroup analysis, and sensitivity analysis, were performed to fully explore the relationship between OBS and CRC, its subsites, and complications. The mediation analysis was conducted to investigate whether serum albumin, uric acid, and neutrophil levels mediate the relationship between OBS and CRC.
After adjusting for potential confounding factors, a significant negative correlation was found between OBS and the risk of CRC and its subsites (proximal colon cancer, distal colon cancer, and rectal cancer). This correlation was particularly pronounced in male CRC patients. Serum albumin, uric acid, and neutrophil count, which are biomarkers, were found to have a significant mediating effect between OBS and CRC.
Our study suggests that higher exposure to antioxidants assessed through OBS (diet and lifestyle rich in antioxidants) may decrease the occurrence of CRC and its subsites.
氧化平衡评分（OBS）常用于评估氧化应激，并对饮食和生活方式相关暴露进行全面评估。然而，关于 OBS 与结直肠癌（CRC）及其亚部位和常见并发症之间的关联，研究有限。本研究旨在评估 OBS 与大型前瞻性队列研究中 CRC、其亚部位和常见并发症风险之间的关系。
我们纳入了 2006 年至 2010 年英国生物样本库数据样本库中 175808 名参与者的数据。我们使用基于 22 种饮食和生活方式因素的评分系统评估 OBS。进行了多种调整，包括多变量 Cox 比例风险回归、性别分层、亚组分析和敏感性分析，以充分探讨 OBS 与 CRC、其亚部位和并发症之间的关系。进行了中介分析，以探讨血清白蛋白、尿酸和中性粒细胞水平是否介导 OBS 与 CRC 之间的关系。
在调整了潜在混杂因素后，OBS 与 CRC 及其亚部位（近端结肠癌、远端结肠癌和直肠癌）的风险之间存在显著负相关。这种相关性在男性 CRC 患者中更为明显。血清白蛋白、尿酸和中性粒细胞计数作为生物标志物，在 OBS 与 CRC 之间具有显著的中介作用。
我们的研究表明，通过 OBS（富含抗氧化剂的饮食和生活方式）评估的抗氧化剂暴露增加可能会降低 CRC 及其亚部位的发生风险。
