Nck, a melanoma cDNA encoding a cytoplasmic protein consisting of the src homology units SH2 and SH3.
作者信息
Lehmann J M, Riethmüller G, Johnson J P
机构信息
Institute for Immunology, Munich, FRG.
出版信息
Nucleic Acids Res. 1990 Feb 25;18(4):1048. doi: 10.1093/nar/18.4.1048.
Abstract
摘要
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Nck, a melanoma cDNA encoding a cytoplasmic protein consisting of the src homology units SH2 and SH3.Nck，一种黑色素瘤cDNA，编码一种由src同源结构域SH2和SH3组成的细胞质蛋白。
Nucleic Acids Res. 1990 Feb 25;18(4):1048. doi: 10.1093/nar/18.4.1048.
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Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries.从人和大鼠cDNA文库中克隆ASH，一种由一个Src同源区域（SH）2和两个SH3结构域组成的普遍存在的蛋白质。
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Molecular identification of a major palmitoylated erythrocyte membrane protein containing the src homology 3 motif.含有src同源3基序的主要棕榈酰化红细胞膜蛋白的分子鉴定。
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An ocular melanoma-associated antigen. Molecular characterization.一种眼黑色素瘤相关抗原。分子特征
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The melanoma progression-associated antigen P3.58 is identical to the intercellular adhesion molecule, ICAM-1.黑色素瘤进展相关抗原P3.58与细胞间黏附分子ICAM-1相同。
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High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains.具有Src同源2结构域的表皮生长因子受体结合蛋白的高效表达/克隆
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src-related protein tyrosine kinases.
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Rapid Actions of the Nuclear Progesterone Receptor through cSrc in Cancer.核孕激素受体通过 cSrc 在癌症中的快速作用。
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Nck adaptors at a glance.Nck 衔接蛋白概述。
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Sinner or Saint?: Nck Adaptor Proteins in Vascular Biology.罪人还是圣徒？血管生物学中的Nck衔接蛋白
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Actin polymerization regulates recruitment of Nck to CD3ε upon T-cell receptor triggering.肌动蛋白聚合调节 T 细胞受体触发后 Nck 向 CD3ε 的募集。
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Expression of GADS enhances FLT3-induced mitogenic signaling.GADS的表达增强了FLT3诱导的促有丝分裂信号传导。
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Non-overlapping functions of Nck1 and Nck2 adaptor proteins in T cell activation.Nck1 和 Nck2 衔接蛋白在 T 细胞激活中的非重叠功能。
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Depletion of the adaptor protein NCK increases UV-induced p53 phosphorylation and promotes apoptosis.衔接蛋白 NCK 的耗竭增加了 UV 诱导的 p53 磷酸化并促进了细胞凋亡。
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Coordinated activation of the Rac-GAP β2-chimaerin by an atypical proline-rich domain and diacylglycerol.β2-奇美拉蛋白通过非典型脯氨酸丰富结构域和二酰基甘油协调激活 Rac-GAP。
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Essential role of the adaptor protein Nck1 in Jurkat T cell activation and function.衔接蛋白 Nck1 在 Jurkat T 细胞激活和功能中的重要作用。
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Nck2 promotes human melanoma cell proliferation, migration and invasion in vitro and primary melanoma-derived tumor growth in vivo.Nck2 促进人黑色素瘤细胞在体外的增殖、迁移和侵袭以及原代黑色素瘤衍生的肿瘤在体内的生长。
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本文引用的文献
1
Oncogenes and cell control.癌基因与细胞调控。
Nature. 1988 Mar 17;332(6161):203. doi: 10.1038/332203a0.
2
MUC18, a marker of tumor progression in human melanoma, shows sequence similarity to the neural cell adhesion molecules of the immunoglobulin superfamily.MUC18是人类黑色素瘤中肿瘤进展的标志物，与免疫球蛋白超家族的神经细胞黏附分子具有序列相似性。
Proc Natl Acad Sci U S A. 1989 Dec;86(24):9891-5. doi: 10.1073/pnas.86.24.9891.
3
Similarity in membrane proteins.膜蛋白的相似性。
Nature. 1989 Dec 7;342(6250):624. doi: 10.1038/342624a0.
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