Section of Endocrinology and Diabetes, St. Christopher's Hospital for Children, Department of Pediatrics, Drexel University College of Medicine, Philadelphia, PA, USA.
J Pediatr. 2011 Apr;158(4):628-633.e1. doi: 10.1016/j.jpeds.2010.09.081.
To evaluate whether oxidative stress is correlated with adiposity, obesity-related metabolic abnormalities, and ambulatory blood pressure (ABP) in a multi-ethnic pediatric population.
We conducted a prospective study enrolling 42 obese children (age, 12.8 ± 2.4 years) and 34 non-obese children (age, 11.8 ± 3.4 years). We measured urine 8-isoprostane and hydrogen peroxide (markers of oxidative stress) in both obese and non-obese groups. In the obese group, we measured the 24-hour ABP and obtained an oral glucose tolerance test, lipid panel, interleukin-6, and tumor necrosis factor-α.
8-isoprostane and hydrogen peroxide were correlated with body mass index standard deviation score and waist circumference. The mean 8-isoprostane and hydrogen peroxide levels of the obese group were higher than those of the non-obese group. In the subset of obese subjects who underwent ABP monitoring, 8-isoprostane was correlated with mean 24-hour systolic blood pressure: within the obese group, 8-isoprostane was higher in obese children with elevated mean 24-hour systolic blood pressure.
Our findings provide evidence of a significant correlation between oxidative stress, adiposity, and blood pressure in children. Longitudinal studies in a larger population sample are needed to validate the association between elevated urine 8-isoprostane level and cardiovascular risk factors in an obese pediatric population.
评估在多民族儿科人群中，氧化应激是否与肥胖、肥胖相关代谢异常以及动态血压（ABP）相关。
我们进行了一项前瞻性研究，纳入 42 名肥胖儿童（年龄为 12.8 ± 2.4 岁）和 34 名非肥胖儿童（年龄为 11.8 ± 3.4 岁）。我们测量了肥胖组和非肥胖组的尿液 8-异前列腺素和过氧化氢（氧化应激标志物）。在肥胖组中，我们测量了 24 小时 ABP，并进行了口服葡萄糖耐量试验、血脂谱、白细胞介素-6 和肿瘤坏死因子-α检测。
8-异前列腺素和过氧化氢与体重指数标准差评分和腰围相关。肥胖组的 8-异前列腺素和过氧化氢平均水平高于非肥胖组。在接受 ABP 监测的肥胖受试者亚组中，8-异前列腺素与 24 小时平均收缩压相关：在肥胖组中，24 小时平均收缩压升高的肥胖儿童 8-异前列腺素水平更高。
我们的研究结果提供了儿童中氧化应激、肥胖和血压之间存在显著相关性的证据。需要在更大的人群样本中进行纵向研究，以验证肥胖儿童尿液 8-异前列腺素水平升高与心血管危险因素之间的关联。
