Casazza J P, Song B J, Veech R L
Laboratory of Metabolism and Molecular Biology, National Institute on Alcoholism and Alcohol Abuse, Rockville, MD 20852.
Trends Biochem Sci. 1990 Jan;15(1):26-30. doi: 10.1016/0968-0004(90)90127-w.
Recent clinical studies have shown the presence of two short chain diols, meso-2,3-butanediol and D/L-2,3-butanediol, and in most cases 1,2-propanediol in either serum or urine collected from humans in several apparently unrelated disease states: congenital propionic and methylmalonic acidemia, premature infants, and alcoholics both in the presence and absence of ethanol. In addition 1,2-propanediol has been shown in patients during prolonged starvation, and in patients with diabetic keto-acidosis. No common defect is known to exist in these metabolic states. Understanding how these compounds are produced in clinically well-defined diseases such as methyl malonic and propionic aciduria, however, may help explain how and why these compounds are produced in alcoholics.
最近的临床研究表明，在从患有几种明显不相关疾病状态的人类身上采集的血清或尿液中存在两种短链二醇，即内消旋-2,3-丁二醇和D/L-2,3-丁二醇，并且在大多数情况下还存在1,2-丙二醇，这些疾病状态包括先天性丙酸血症和甲基丙二酸血症、早产儿以及酗酒者（无论是否存在乙醇）。此外，在长期饥饿的患者以及患有糖尿病酮症酸中毒的患者体内也发现了1,2-丙二醇。目前已知在这些代谢状态中不存在共同的缺陷。然而，了解这些化合物在临床上明确的疾病（如甲基丙二酸尿症和丙酸尿症）中是如何产生的，可能有助于解释这些化合物在酗酒者体内是如何以及为何产生的。
