Masuya Hiroshi, Makita Yuko, Kobayashi Norio, Nishikata Koro, Yoshida Yuko, Mochizuki Yoshiki, Doi Koji, Takatsuki Terue, Waki Kazunori, Tanaka Nobuhiko, Ishii Manabu, Matsushima Akihiro, Takahashi Satoshi, Hijikata Atsushi, Kozaki Kouji, Furuichi Teiichi, Kawaji Hideya, Wakana Shigeharu, Nakamura Yukio, Yoshiki Atsushi, Murata Takehide, Fukami-Kobayashi Kaoru, Mohan Sujatha, Ohara Osamu, Hayashizaki Yoshihide, Mizoguchi Riichiro, Obata Yuichi, Toyoda Tetsuro
RIKEN BioResource Center, Tsukuba, Japan.
Nucleic Acids Res. 2011 Jan;39(Database issue):D861-70. doi: 10.1093/nar/gkq1078. Epub 2010 Nov 13.
The RIKEN integrated database of mammals (http://scinets.org/db/mammal) is the official undertaking to integrate its mammalian databases produced from multiple large-scale programs that have been promoted by the institute. The database integrates not only RIKEN's original databases, such as FANTOM, the ENU mutagenesis program, the RIKEN Cerebellar Development Transcriptome Database and the Bioresource Database, but also imported data from public databases, such as Ensembl, MGI and biomedical ontologies. Our integrated database has been implemented on the infrastructure of publication medium for databases, termed SciNetS/SciNeS, or the Scientists' Networking System, where the data and metadata are structured as a semantic web and are downloadable in various standardized formats. The top-level ontology-based implementation of mammal-related data directly integrates the representative knowledge and individual data records in existing databases to ensure advanced cross-database searches and reduced unevenness of the data management operations. Through the development of this database, we propose a novel methodology for the development of standardized comprehensive management of heterogeneous data sets in multiple databases to improve the sustainability, accessibility, utility and publicity of the data of biomedical information.
