Ren J, Pang Z C, Gao W G, Nan H R, Wang S J, Zhang L, Qiao Q
Department of Epidemiology and Health Statistics, Shandong University, Jinan, China.
Exp Diabetes Res. 2010;2010:761715. doi: 10.1155/2010/761715. Epub 2010 Nov 7.
To investigate the association of C-reactive protein (CRP) and gamma glutamyltransferase (GGT) concentrations with newly diagnosed diabetes defined by either glucose or HbA1c criteria in Chinese adults.
A population-based cross-sectional study was conducted in 2006. Data from 1167 men and 1607 women aged 35-74 years were analyzed. Diabetes was defined according to either glucose or HbA1c criteria alone.
Compared with nondiabetes, multivariate-adjusted OR (95%CI) was 1.13 (0.90,1.42) in men and 1.21 (1.00,1.45) in women for CRP and 1.42 (1.18,1.72) and 1.57 (1.31,1.87) for GGT, respectively. Neither CRP nor GGT was associated with the presence of diabetes defined by the HbA1c criterion.
The effect of elevated CRP on diabetes defined by the glucose criterion was mediated through obesity, but elevated GGT was an independent risk factor for diabetes in this Chinese population. None of the two was, however, associated with the elevated HbA1c concentrations.
在中国成年人中，研究C反应蛋白（CRP）和γ-谷氨酰转移酶（GGT）浓度与根据血糖或糖化血红蛋白（HbA1c）标准新诊断的糖尿病之间的关联。
2006年开展了一项基于人群的横断面研究。分析了1167名年龄在35 - 74岁的男性和1607名女性的数据。糖尿病仅根据血糖或HbA1c标准进行定义。
与非糖尿病患者相比，经多变量调整后，男性CRP的比值比（OR，95%置信区间）为1.13（0.90, 1.42），女性为1.21（1.00, 1.45）；男性GGT的OR为1.42（1.18, 1.72），女性为1.57（1.31, 1.87）。CRP和GGT均与根据HbA1c标准定义的糖尿病存在无关。
CRP升高对根据血糖标准定义的糖尿病的影响是通过肥胖介导的，但GGT升高是该中国人群糖尿病的独立危险因素。然而，两者均与HbA1c浓度升高无关。
