Department of Otolaryngology-Head and Neck Surgery, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA.
J Oncol. 2011;2011:762780. doi: 10.1155/2011/762780. Epub 2010 Nov 8.
Accumulating evidence suggests that self-renewal and differentiation capabilities reside only in a subpopulation of tumor cells, termed cancer stem cells (CSCs), whereas the remaining tumor cell population lacks the ability to initiate tumor development or support continued tumor growth. In head and neck squamous cell carcinoma (HNSCC), as with other malignancies, cancer stem cells have been increasingly shown to have an integral role in tumor initiation, disease progression, metastasis and treatment resistance. In this paper we summarize the current knowledge of the role of CSCs in HNSCC and discuss the therapeutic implications and future directions of this field.
越来越多的证据表明，自我更新和分化能力仅存在于肿瘤细胞的一个亚群中，称为癌症干细胞（CSCs），而其余的肿瘤细胞群则缺乏启动肿瘤发展或支持肿瘤持续生长的能力。在头颈部鳞状细胞癌（HNSCC）中，与其他恶性肿瘤一样，癌症干细胞在肿瘤起始、疾病进展、转移和治疗耐药性方面的作用越来越受到重视。本文总结了 CSCs 在 HNSCC 中的作用的现有知识，并讨论了该领域的治疗意义和未来方向。
