Faculty of Health, University of Newcastle, University Drive, Callaghan, NSW 2308, Australia.
Int Arch Occup Environ Health. 2011 Oct;84(7):723-33. doi: 10.1007/s00420-010-0600-9. Epub 2010 Nov 14.
The purpose of the study was to examine possible persisting effects to color vision in a group from the Royal Australian Air Force who had exposure to formulations containing neurotoxins during F-111 fuel tank maintenance, relative to two contemporaneous comparison groups.
Color vision was tested in 512 exposed personnel, 458 technical-trade comparisons, and 330 non-technical comparisons using the Ishihara test plates and the Lanthony D-15 Desaturated Color disk arrangement test. Participants were excluded if they failed the Ishihara test as this indicates congenital color blindness. From the Lanthony results, the type of color deficient vision (CDV) was diagnosed, and additionally, the Bowman's color confusion index (CCI) was calculated. Regression models were used to examine whether there was an association between color vision deficiencies and F-111 fuel tank maintenance, adjusting for possible confounders.
The CCI ranged from 1 to 2.8 (median 1.2, quartiles 1.1, 1.4) in the 2,600 eyes tested. Forty five percent of all participants had blue-yellow CDV in at least one eye. Deficiencies of this nature are caused by environmental exposures. Logistic regression demonstrated statistically significant differences in CCI category in the exposed group versus technical group (odds ratio 1.7: 95% CI 1.3-2.0) and a blue-yellow confusion in the exposed group versus technical group (odds ratio 1.4: 95% CI 1.1-1.7). No differences were observed between the exposed group and the non-technical group.
The results indicate reduced color discrimination among the exposed subjects compared to one of two control groups. The findings may be due to previous exposure to solvents among the air force personnel.
本研究旨在检查曾接触过 F-111 燃料箱维护过程中含神经毒素制剂的澳大利亚皇家空军一组人员的色觉是否存在持续影响，并与两个同期对照组进行比较。
使用 Ishihara 测试板和 Lanthony D-15 消色圆盘排列测试对 512 名暴露人员、458 名技术行业比较人员和 330 名非技术行业比较人员进行色觉测试。如果参与者无法通过 Ishihara 测试，则将其排除在外，因为这表明存在先天性色觉缺陷。根据 Lanthony 的结果，诊断出色觉缺陷的类型，并计算 Bowman 色觉混淆指数（CCI）。回归模型用于检查色觉缺陷与 F-111 燃料箱维护之间是否存在关联，同时调整可能的混杂因素。
在测试的 2600 只眼中，CCI 范围为 1 至 2.8（中位数 1.2，四分位数 1.1、1.4）。45%的参与者至少一只眼睛存在蓝黄色色觉缺陷。这种性质的缺陷是由环境暴露引起的。逻辑回归显示，暴露组与技术组的 CCI 类别存在统计学显著差异（比值比 1.7：95%置信区间 1.3-2.0），且暴露组与技术组之间存在蓝黄色混淆（比值比 1.4：95%置信区间 1.1-1.7）。暴露组与非技术组之间未观察到差异。
结果表明，与两个对照组之一相比，暴露组的色觉辨别能力下降。这些发现可能是由于空军人员之前接触过溶剂。
