University of Texas M.D. Anderson Cancer Center, Unit 1330, P.O. Box 301439, Houston, TX 77230-1439, USA.
Curr Oncol Rep. 2011 Feb;13(1):71-6. doi: 10.1007/s11912-010-0139-7.
The prevalence of overweight and obesity is increasing worldwide, and the evidence base for a link between obesity and cancer is growing. In the United States, approximately 85,000 new cancer cases per year are related to obesity. Recent research has found that as the body mass index increases by 5 kg/m2, cancer mortality increases by 10%. Additionally, studies of patients who have had bariatric surgery for weight loss report reductions in cancer incidence and mortality, particularly for women. The goal of this review is to provide an update of recent research, with a focus on epidemiologic studies on the link between obesity and cancer. In addition, we will briefly review hypothesized mechanisms underlying the relationship between obesity and cancer. High priorities for future research involve additional work on the underlying mechanisms, and trials to examine the effect of lifestyle behavior change and weight loss interventions on cancer and intermediate biomarkers.
超重和肥胖的患病率在全球范围内不断上升，肥胖与癌症之间关联的证据也在不断增加。在美国，每年约有 85000 例新的癌症病例与肥胖有关。最近的研究发现，随着体重指数增加 5kg/m2，癌症死亡率增加 10%。此外，对接受减重手术以减肥的患者进行的研究报告称，癌症发病率和死亡率降低，特别是对女性而言。本次综述的目的是提供最近研究的最新信息，重点关注肥胖与癌症之间关联的流行病学研究。此外，我们还将简要回顾肥胖与癌症之间关系的假设机制。未来研究的重点是进一步研究潜在机制，并开展试验以研究生活方式行为改变和减肥干预对癌症和中间生物标志物的影响。
