Department of Neurology, Haukeland University Hospital, Bergen, Norway.
Cancer Immunol Immunother. 2011 Feb;60(2):283-9. doi: 10.1007/s00262-010-0943-9. Epub 2010 Nov 16.
Paraneoplastic cerebellar degeneration (PCD) is often associated with Yo antibodies that are directed against human cerebellar degeneration-related protein 2 (CDR2). Such antibodies may also be found in ovarian cancer patients without PCD. We studied if there was an association between Yo antibody production and differences in CDR2 cDNA sequence, mRNA or CDR2 expression in ovarian cancers. We found similar CDR2 cDNA sequence, mRNA and protein levels in primary ovarian cancers, with or without associated Yo antibodies. CDR2 was also present in other cancers, as well as in normal ovary tissue. The results suggest that Yo antibodies are not only related to the expression of CDR2 alone, but also to immune dysregulation.
副肿瘤性小脑变性（PCD）常与针对人类小脑变性相关蛋白 2（CDR2）的 Yo 抗体有关。此类抗体也可能存在于无 PCD 的卵巢癌患者中。我们研究了 Yo 抗体产生与卵巢癌中 CDR2 cDNA 序列、mRNA 或 CDR2 表达差异之间是否存在关联。我们发现，无论是否伴有 Yo 抗体，原发性卵巢癌中 CDR2 的 cDNA 序列、mRNA 和蛋白水平相似。CDR2 也存在于其他癌症以及正常卵巢组织中。结果表明，Yo 抗体不仅与 CDR2 的表达有关，还与免疫失调有关。
