Soares Andresa Borges, Thomaz Luiz Alexandre, Duarte Mauricio Texeira, de Camargo de Moraes Paulo, de Araújo Vera Cavalcanti
Institute and Research Center São Leopoldo Mandic, Campinas, SP, Brazil.
Head Neck Pathol. 2011 Jun;5(2):140-3. doi: 10.1007/s12105-010-0222-2. Epub 2010 Nov 16.
A case of gingival metastasis of adenocarcinoma of the colon is reported, the lesion being an early clinical indication of a primary malignant tumor. The diagnosis of metastatic lesion in the oral region is always challenging, both to clinician and to the pathologist, due to its rarity and complexity. In the present case, the clinical hypothesis was peripheral ossifying fibroma or pyogenic granuloma. Histologically, the biopsy tissue revealed a malignant neoplasm not connected to the mucosal surface. Immunohistochemically, the lesion was positive for 35ßH11 and cytokeratin 20 and focally positive for cytokeratin 7. Treatment involved excision of primary tumor and follow-up chemotherapy. The clinical, histological and immunohistochemical characteristics are discussed.
本文报道了一例结肠癌牙龈转移病例，该病变是原发性恶性肿瘤的早期临床指征。由于口腔区域转移病变罕见且复杂，因此对临床医生和病理学家而言，其诊断始终具有挑战性。在本病例中，临床初步诊断为外周骨化性纤维瘤或化脓性肉芽肿。组织学检查显示，活检组织为与黏膜表面不相连的恶性肿瘤。免疫组化结果显示，该病变对35ßH11和细胞角蛋白20呈阳性反应，对细胞角蛋白7呈局灶性阳性反应。治疗方法包括切除原发性肿瘤及后续化疗。文中讨论了该病例的临床、组织学及免疫组化特征。
