Department of Pathology and the Life Sciences Institute, University of Michigan, 210 Washtenaw Ave., Ann Arbor, MI 48109, USA.
Chem Commun (Camb). 2011 Jan 7;47(1):529-31. doi: 10.1039/c0cc02253e. Epub 2010 Nov 16.
A series of dihydropyridines were identified that have an effect on the accumulation of tau, an important target in Alzheimer's disease. The dihydropyridine collection was expanded using the Hantzsch multicomponent reaction to develop preliminary structure-activity relationships.
一系列二氢吡啶类化合物被鉴定出来,它们对tau 的积累有影响,tau 是阿尔茨海默病的一个重要靶点。使用 Hantzsch 多组分反应扩展了二氢吡啶库,以开发初步的结构-活性关系。