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Multicomponent reactions in crop protection chemistry.
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Design, Synthesis, and Biological Evaluation of 1,4-dihydropyridine Derivatives as Potent Antitubercular Agents.
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1,4-Dihydropyridine: synthetic advances, medicinal and insecticidal properties.
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Inhibitors of heat shock protein 70 (Hsp70) with enhanced metabolic stability reduce tau levels.
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Intercepted-Knoevenagel condensation for the synthesis of unsymmetrical fused-tricyclic 4-pyrans.
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Tau Protein Squired by Molecular Chaperones During Alzheimer's Disease.
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Transcriptional Inhibitors Identified in a 160,000-Compound Small-Molecule DUX4 Viability Screen.
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The molecular diversity scope of 1,3-indandione in organic synthesis.
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Pharmacological tuning of heat shock protein 70 modulates polyglutamine toxicity and aggregation.
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Chemical manipulation of hsp70 ATPase activity regulates tau stability.
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Enantioselective organocatalytic Hantzsch synthesis of polyhydroquinolines.
Org Lett. 2009 Jul 16;11(14):2957-9. doi: 10.1021/ol901114f.
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Chaperone signalling complexes in Alzheimer's disease.
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Synthesis of new acridines and hydrazones derived from cyclic beta-diketone for cytotoxic and antiviral evaluation.
Eur J Med Chem. 2009 Sep;44(9):3680-6. doi: 10.1016/j.ejmech.2009.04.001. Epub 2009 Apr 8.
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Tau pathophysiology in neurodegeneration: a tangled issue.
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Tau mutations in neurodegenerative diseases.
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The natively unfolded character of tau and its aggregation to Alzheimer-like paired helical filaments.
Biochemistry. 2008 Oct 7;47(40):10526-39. doi: 10.1021/bi800783d. Epub 2008 Sep 11.
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Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases.
Nat Rev Drug Discov. 2007 Jun;6(6):464-79. doi: 10.1038/nrd2111.
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The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins.
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