Biomechanics Laboratory-III Clinic, Rizzoli Orthopaedic Institute, Via Di Barbiano 1/10, 40136, Bologna, Italy.
Knee Surg Sports Traumatol Arthrosc. 2011 Apr;19(4):516-27. doi: 10.1007/s00167-010-1306-y. Epub 2010 Nov 17.
Tissue repair in musculoskeletal lesions is often a slow and sometimes incomplete process. In sports patients or professional athletes, the impact of musculoskeletal lesions on life and work is great, and the fast recovery of full efficiency and return to competition is of primary importance. The clinical improvement offered by available treatments is not always sufficient for highly demanding patients to return to their previous level of activity. The search for a minimally invasive solution to improve the status of the chondral surface of the injured joint is therefore highly desirable, especially in these patients. Platelet-rich plasma (PRP) is a procedure that allows to obtain a natural concentration of autologous growth factors. The attractive possibility to use the patients' own growth factors to enhance reparative process in tissues with low healing potential, the promising preliminary clinical findings and the safety of these methods, explain the wide application of this biological approach. The aim of this review is to analyse the existing published studies to look for scientific evidence in preclinical studies or in the results obtained through PRP application in humans that supports the efficacy of PRP and its use for the treatment of tendinous, ligamentous, cartilaginous and muscular injuries. The analysis of the literature shows promising preclinical results but contradictory clinical findings for the treatment of sport injuries. High-quality studies are required to confirm these preliminary results and provide scientific evidence to support its use.
在肌肉骨骼病变中，组织修复通常是一个缓慢的过程，有时甚至是不完全的。在运动患者或职业运动员中，肌肉骨骼病变对生活和工作的影响是巨大的，快速恢复全部效率并重返比赛至关重要。现有治疗方法提供的临床改善对于要求极高的患者来说并不总是足以使其恢复到以前的活动水平。因此，人们强烈希望寻找一种微创解决方案来改善受伤关节软骨表面的状况，尤其是在这些患者中。富含血小板的血浆 (PRP) 是一种可以获得自体生长因子自然浓度的程序。使用患者自身的生长因子来增强低愈合潜能组织的修复过程的诱人可能性、有前途的初步临床发现以及这些方法的安全性，解释了这种生物方法的广泛应用。本综述的目的是分析现有的已发表研究，以寻找支持 PRP 疗效及其在治疗肌腱、韧带、软骨和肌肉损伤中的应用的科学证据，这些证据来自于临床前研究或 PRP 在人类中的应用结果。文献分析显示，PRP 在治疗运动损伤方面具有有前景的临床前结果，但临床结果存在矛盾。需要高质量的研究来证实这些初步结果，并提供支持其使用的科学证据。
