模块化聚合物笼纳米盒作为一种治疗诊断平台，具有增强的磁共振弛豫率和 pH 响应药物释放。
Modular polymer-caged nanobins as a theranostic platform with enhanced magnetic resonance relaxivity and pH-responsive drug release.
机构信息
Department of Chemistry and the Center of Cancer Nanotechnology Excellence, Northwestern University, 2145 Sheridan Rd. Evanston, IL 60208-3113, USA.
出版信息
Angew Chem Int Ed Engl. 2010 Dec 17;49(51):9960-4. doi: 10.1002/anie.201004867.
Abstract
‘Clickable’ polymer-caged nanobins enable the combination of Gd MRI contrast agents and an anticancer drug (gemcitabine, GMC) into a single theranostic platform. The resulting Gd-conjugated, GMC-loaded PCNs (Gd-PCN) exhibit significant enhancements in relaxivity, drug uptake, and pH-sensitive drug release.
摘要
‘可点击’聚合物笼纳米盒使 Gd MRI 造影剂和一种抗癌药物（吉西他滨，GMC）结合到一个单一的治疗平台。所得的 Gd 结合的、GMC 负载的 PCN（Gd-PCN）在弛豫率、药物摄取和 pH 敏感的药物释放方面表现出显著的增强。
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