Kulthanan Kanokvalai, Wongkamchai Sirichit, Triwongwaranat Daranporn
Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
J Dermatol. 2010 Dec;37(12):1025-31. doi: 10.1111/j.1346-8138.2010.00958.x. Epub 2010 Aug 17.
Mosquito bite allergic reactions are due to sensitization to mosquito salivary proteins. The purpose of our study was to assess the clinical features of Thai patients with mosquito allergy, and to define the natural desensitization course. Seventy patients with mosquito allergy were enrolled. Most patients were female. Half of the patients had a personal history of atopy. The average age of onset of mosquito reaction was 5.7 years old (range 2-58). Four patients were in the desensitization phase in which clinical symptoms disappeared within 9.5 years (median). The common cutaneous lesions were erythematous papules (68.6%) and immediate wheals (67.1%). The most common area of involvement was the leg. Forty of 50 patients (80%) had positive skin prick testing to mosquito allergen (Culex quinquefasciatus) and 31 of 42 patients (73.8%) had positive immunoglobulin E antibodies against allergens in C. quinquefasciatus saliva proteins.
蚊虫叮咬过敏反应是由于对蚊虫唾液蛋白致敏所致。我们研究的目的是评估泰国蚊虫过敏患者的临床特征，并确定自然脱敏过程。招募了70名蚊虫过敏患者。大多数患者为女性。一半患者有特应性个人史。蚊虫反应的平均发病年龄为5.7岁（范围2 - 58岁）。4名患者处于脱敏阶段，临床症状在9.5年（中位数）内消失。常见的皮肤损害为红斑丘疹（68.6%）和速发风团（67.1%）。最常受累的部位是腿部。50名患者中有40名（80%）对蚊虫过敏原（致倦库蚊）皮肤点刺试验呈阳性，42名患者中有31名（73.8%）针对致倦库蚊唾液蛋白中的过敏原免疫球蛋白E抗体呈阳性。
