在“Generation R研究”中，婴儿金黄色葡萄球菌与肺炎链球菌定植之间的负相关关系无法用血清抗体水平差异来解释。
The inverse correlation between Staphylococcus aureus and Streptococcus pneumoniae colonization in infants is not explained by differences in serum antibody levels in the Generation R Study.
作者信息
Lebon Ankie, Verkaik Nelianne J, de Vogel Corné P, Hooijkaas Herbert, Verbrugh Henri A, van Wamel Willem J B, Jaddoe Vincent W V, Hofman Albert, Hermans Peter W M, Mitchell Tim J, Moll Henriette A, van Belkum Alex
机构信息
The Generation R Study Group, Erasmus Medical Center (Erasmus MC), Rotterdam, Netherlands.
出版信息
Clin Vaccine Immunol. 2011 Jan;18(1):180-3. doi: 10.1128/CVI.00357-10. Epub 2010 Nov 17.
Abstract
Colonization rates of Streptococcus pneumoniae and Staphylococcus aureus are inversely correlated in infants. Several studies have searched for determinants of this negative association. We studied the association between antipneumococcal antibodies with Staphylococcus aureus colonization and the association between antistaphylococcal antibodies with pneumococcal colonization in healthy children in the pneumococcal vaccine era. In the first year of life, no association between maternal IgG levels and colonization was seen. In addition, no association between the IgG and IgA levels in the child versus colonization status was seen.
摘要
肺炎链球菌和金黄色葡萄球菌在婴儿中的定植率呈负相关。多项研究探寻了这种负相关的决定因素。我们研究了肺炎球菌疫苗时代健康儿童中抗肺炎球菌抗体与金黄色葡萄球菌定植之间的关联，以及抗葡萄球菌抗体与肺炎球菌定植之间的关联。在生命的第一年，未观察到母体IgG水平与定植之间存在关联。此外，也未观察到儿童的IgG和IgA水平与定植状态之间存在关联。
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