Marusić A, Kos K, Stavljenić A, Vukicević S
Department of Anatomy, School of Medicine, University of Zagreb, Yugoslavia.
Inflammation. 1990 Apr;14(2):205-16. doi: 10.1007/BF00917459.
We investigated the dynamics of the acute-phase response (APR) and osteoblast trabecular surface in rats with subcutaneous inflammation provoked by magnesium silicate (talc). The first visible indicator of the APR was a rapid and profound hypozincemia, paralleled by a decrease in metaphyseal trabecular surfaces covered with osteoblasts in long bones. Both the intensity of serum APR and the decrease in osteoblast trabecular surface were directly proportional to the number of granulomas. Alterations in bone metabolism were specific for the inflammation, whereas mild hypozincemia and decrease in mononuclear and increase in polymorphonuclear peripheral white blood cell fractions developed in animals pair-fed with rats bearing two or four granulomas. Rats with talc granulomatosis had high serum ACTH and corticosterone levels, but neither adrenalectomy nor high doses of hydrocortisone could revert bone alterations in talc-injected animals. Glucocorticoids were necessary for the development of hypozincemia and hypercupremia seen in talc granulomatosis, as well as for normal bone metabolism. Inhibition of prostaglandin synthesis had no effect on bone alterations and serum APR in rats bearing talc-induced granulomas. We conclude that the decrease in bone formation constitutes an important aspect of the host acute-phase response in a rat model of talc granulomatosis.
我们研究了由硅酸镁（滑石粉）诱发皮下炎症的大鼠急性期反应（APR）和成骨细胞小梁表面的动态变化。APR的首个明显指标是迅速且显著的低锌血症，同时长骨中覆盖有成骨细胞的干骺端小梁表面减少。血清APR的强度和成骨细胞小梁表面的减少均与肉芽肿数量成正比。骨代谢的改变是炎症所特有的，而在与患有两个或四个肉芽肿的大鼠配对喂养的动物中，出现了轻度低锌血症、单核细胞减少以及多形核外周白细胞分数增加。患有滑石粉肉芽肿病的大鼠血清促肾上腺皮质激素（ACTH）和皮质酮水平较高，但肾上腺切除术或高剂量氢化可的松均无法使滑石粉注射动物的骨骼改变恢复正常。糖皮质激素对于滑石粉肉芽肿病中出现的低锌血症和高铜血症的发展以及正常骨代谢是必需的。前列腺素合成的抑制对患有滑石粉诱导肉芽肿的大鼠的骨骼改变和血清APR没有影响。我们得出结论，在滑石粉肉芽肿病大鼠模型中，骨形成减少是宿主急性期反应的一个重要方面。
