Loktin E M, Firsov S A, Pliaskin A E, Antonov A R
Klin Med (Mosk). 2010;88(5):46-8.
Generalized peritonitis is one of the most adequate clinical models of inflammatory processes with pronounced polyorgan insufficiency in which immunological reactivity may be substantially modified by any intoxicant of exogenous origin, e.g., alcohol. The aim of the present work was to assess immunological status of patients with generalized peritonitis associated with acute and chronic alcoholic intoxication treated by discrete plasmapheresis. A total of 152 men (mean age 49.7 +/- 1.2 years) were examined in Novosibirsk city clinical hospital No 2. Peritonitis developed within the average of 48.2 hours. All the patients with peritonitis experienced a change of immunological responsiveness under effect of such powerful complicating factor as alcoholic intoxication.
弥漫性腹膜炎是炎症过程中最典型的临床模型之一，伴有明显的多器官功能不全，在外源性任何毒物（如酒精）作用下，免疫反应性可能会发生显著改变。本研究旨在评估采用间断性血浆置换治疗的合并急性和慢性酒精中毒的弥漫性腹膜炎患者的免疫状态。新西伯利亚市第二临床医院共检查了152名男性（平均年龄49.7±1.2岁）。腹膜炎平均在48.2小时内发病。所有腹膜炎患者在酒精中毒这种强大的并发症影响下，免疫反应性均发生了变化。
