Bernstein D, Schiff G, Echler G, Prince A, Feller M, Briner W
Institute of Medical Research, Cincinnati, Ohio 45219.
J Dent Res. 1990 Mar;69(3):874-6. doi: 10.1177/00220345900690030901.
The purpose of this work was to assess the in vitro antiviral effectiveness of a mouthrinse (Peridex) containing 0.12% chlorhexidine gluconate (CH) on several viruses that are associated with the oral cavity. These included herpes simplex virus (HSV), cytomegalovirus (CMV), influenza A, parainfluenza, polio, and hepatitis B (HBV). Virucidal assays in tissue cultures were performed on all viruses except HBV. The virucidal effect on HBV was assessed by inactivation of the DNA polymerase contained within the Dane particle of HBV. The CH mouthrinse had virucidal activity against all of the viruses, except polio, in as little as 30 s. The virucidal activity increased with time. However, there were differences in the responses of these viruses to the challenge of the CH mouthrinse, probably due to subtle differences in the physical/chemical structures of the virus envelopes. Results on DNA polymerase of the HBV virus were similar to those on the other viruses, except polio, suggesting a common mechanism. With respect to this mechanism, it was proposed that CH exerted its antiviral effect on the envelopes of these viruses, and that the absence of an envelope on polio precluded effectiveness against this virus.
这项工作的目的是评估含有0.12%葡萄糖酸氯己定（CH）的漱口水（派丽奥）对几种与口腔相关病毒的体外抗病毒效果。这些病毒包括单纯疱疹病毒（HSV）、巨细胞病毒（CMV）、甲型流感病毒、副流感病毒、脊髓灰质炎病毒和乙型肝炎病毒（HBV）。除HBV外，对所有病毒均进行了组织培养中的杀病毒试验。通过使HBV Dane颗粒内所含的DNA聚合酶失活来评估对HBV的杀病毒作用。CH漱口水对除脊髓灰质炎病毒外的所有病毒在短短30秒内就具有杀病毒活性。杀病毒活性随时间增加。然而，这些病毒对CH漱口水攻击的反应存在差异，这可能是由于病毒包膜物理/化学结构的细微差异所致。HBV病毒DNA聚合酶的结果与除脊髓灰质炎病毒外的其他病毒相似，表明存在共同机制。关于这一机制，有人提出CH对这些病毒的包膜发挥抗病毒作用，而脊髓灰质炎病毒没有包膜，这使得对该病毒无效。
