来自红树林衍生真菌sp. HNWSW-1的代谢产物。

Metabolites From the Mangrove-Derived Fungus sp. HNWSW-1.

作者信息

Cao Xi, Guo Lei, Cai Caihong, Kong Fandong, Yuan Jingzhe, Gai Cuijuan, Dai Haofu, Wang Pei, Mei Wenli

机构信息

Hainan Key Laboratory for Research and Development of Natural Products From Li Folk Medicine, Hainan Institute for Tropical Agricultural Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China.

Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-Industry Technology, Jiangsu Ocean University, Lianyungang, China.

出版信息

Front Chem. 2021 Dec 16;9:773703. doi: 10.3389/fchem.2021.773703. eCollection 2021.

DOI:10.3389/fchem.2021.773703

PMID:34976948

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8717711/

Abstract

Two new benzoic acids, cladoslide A () and cladoslide B (); one new β-carboline derivative, cladospomine (); and one new pyridin-2(1)-one, cladoslide C (), were isolated from the fermentation cultures of the mangrove-derived fungus sp. HNWSW-1, along with the previously reported -acetyl-β-oxotryptamine (), (4,5,11)--cladospolide B (), (4,5,11)--cladospolide B (), and (4,5,11)--cladospolide B (). Their structures were elucidated by spectroscopic analysis, Rh(OCOCF)-induced ECD experiments, and Marfey's method. Compound showed cytotoxicity against the K562 cell line with IC values of 13.10 ± 0.08 M. Moreover, compounds and exhibited inhibitory activity against α-glycosidase with IC values of 0.32 ± 0.01 mM and 0.17 ± 0.01 mM, respectively.

摘要

从源自红树林的真菌Cladosporium sp. HNWSW-1的发酵培养物中分离出两种新的苯甲酸，即枝状滑刃菌素A（）和枝状滑刃菌素B（）；一种新的β-咔啉衍生物，即枝状孢胺（）；以及一种新的吡啶-2(1)-酮，即枝状滑刃菌素C（），同时还分离出了先前报道的N-乙酰基-β-氧代色胺（）、(4,5,11)-三羟基-枝状孢菌素B（）、(4,5,11)-三羟基-枝状孢菌素B（）和(4,5,11)-三羟基-枝状孢菌素B（）。通过光谱分析、Rh(OCOCF3)诱导的ECD实验和马尔菲方法阐明了它们的结构。化合物对K562细胞系显示出细胞毒性，IC50值为13.10±0.08 μM。此外，化合物和对α-糖苷酶表现出抑制活性，IC50值分别为0.32±0.01 mM和0.17±0.01 mM。