5-HT1A 受体在治疗精神分裂症和帕金森病中的治疗作用。
Therapeutic role of 5-HT1A receptors in the treatment of schizophrenia and Parkinson's disease.
机构信息
Laboratory of Pharmacology, Osaka University of Pharmaceutical Sciences, Nasahara, Takatsuki, Osaka, Japan.
出版信息
CNS Neurosci Ther. 2011 Feb;17(1):58-65. doi: 10.1111/j.1755-5949.2010.00211.x. Epub 2010 Nov 21.
Abstract
5-HT(1A) receptors have long been implicated in the pathogenesis and treatment of anxiety and depressive disorders. Recently, several lines of studies have revealed new insights into the therapeutic role of 5-HT(1A) receptors in treating schizophrenia and Parkinson's disease. Specifically, 5-HT(1A) receptors seem to be a promising target for alleviating antipsychotic-induced extrapyramidal side effects (EPS) and cognitive/affective disorders in schizophrenia. In the treatment of patients with Parkinson's disease, 5-HT(1A) agonists are expected to improve not only affective symptoms (e.g., anxiety and depression), but also the core parkinsonian symptoms as well as antiparkinsonian agents-induced side effects (e.g., L-DOPA-induced dyskinesia). Here, the therapeutic mechanisms mediated by 5-HT(1A) receptors in schizophrenia and Parkinson's disease are reviewed. This evidence should encourage discovery of new 5-HT(1A) ligands, which can resolve the unmet clinical needs in the current therapy.
摘要
5-HT(1A) 受体长期以来一直与焦虑和抑郁障碍的发病机制和治疗有关。最近，几条研究线揭示了 5-HT(1A)受体在治疗精神分裂症和帕金森病中的治疗作用的新见解。具体来说，5-HT(1A)受体似乎是缓解精神分裂症中抗精神病药引起的锥体外系副作用 (EPS) 和认知/情感障碍的有希望的靶点。在帕金森病患者的治疗中，预计 5-HT(1A)激动剂不仅能改善情感症状（如焦虑和抑郁），还能改善核心帕金森病症状以及抗帕金森病药物引起的副作用（如 L-DOPA 诱导的运动障碍）。在这里，综述了 5-HT(1A)受体在精神分裂症和帕金森病中的治疗机制。这一证据应该鼓励发现新的 5-HT(1A)配体，以解决当前治疗中未满足的临床需求。
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