Primary lower extremity and genital lymphoedema (GL) is difficult to manage, especially when complicated with severe lymphorrhea. With abundant experience of treatment for lower-extremity lymphoedema (LEL), we performed simultaneous multi-site lymphaticovenular anastomoses (LVAs) for GL with severe lymphorrhea. In two cases of primary LEL and GL, LVAs were performed via 2-cm-long skin incisions using two to three operating microscopes under local anaesthesia. Symptoms of oedema and lymphorrhea improved clinically. LVA is a minimally invasive surgery, which is effective for the treatment of LEL and GL even in primary cases with severe lymphorrhea. Simultaneous multi-site LVAs can serve as the most effective therapy for lymphoedema.