Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, India.
FEBS Lett. 2011 Jan 3;585(1):7-17. doi: 10.1016/j.febslet.2010.11.018. Epub 2010 Nov 20.
Helicobacter pylori causes gastritis, gastric ulcer and gastric cancer. Though DNA replication and its control are central to bacterial proliferation, pathogenesis, virulence and/or dormancy, our knowledge of DNA synthesis in slow growing pathogenic bacteria like H. pylori is still preliminary. Here, we review the current understanding of DNA replication, replication restart and recombinational repair in H. pylori. Several differences have been identified between the H. pylori and Escherichia coli replication machineries including the absence of DnaC, the helicase loader usually conserved in gram-negative bacteria. These differences suggest different mechanisms of DNA replication at initiation and restart of stalled forks in H. pylori.
幽门螺杆菌会引起胃炎、胃溃疡和胃癌。尽管 DNA 复制及其调控是细菌增殖、发病机制、毒力和/或休眠的核心，但我们对缓慢生长的致病菌（如幽门螺杆菌）中 DNA 合成的了解仍然是初步的。在这里，我们综述了目前对幽门螺杆菌 DNA 复制、复制起始和重组修复的理解。在幽门螺杆菌和大肠杆菌的复制机制之间已经发现了几个差异，包括缺乏 DnaC，这是通常在革兰氏阴性菌中保守的解旋酶加载器。这些差异表明在幽门螺杆菌中，停滞的叉起始和起始的 DNA 复制有不同的机制。
