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β-石竹烯对 感染的体外和体内抑制作用。

Inhibitory Effects of β-Caryophyllene on Infection In Vitro and In Vivo.

机构信息

Department of Biomedical Laboratory Science, College of Health Sciences, Yonsei University, Wonju 26493, Korea.

Department of Clinical Laboratory Science, College of Medical Sciences, Daegu Haany University, Gyeongsan 38610, Korea.

出版信息

Int J Mol Sci. 2020 Feb 3;21(3):1008. doi: 10.3390/ijms21031008.

DOI:10.3390/ijms21031008
PMID:32028744
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7037973/
Abstract

The human specific bacterial pathogen () is associated with severe gastric diseases, including gastric cancer. Recently, the increasing resistance makes the usage of antibiotics less effectively. Therefore, development of a new antimicrobial agent is required to control infection. In the current study, the inhibitory effect of β-caryophyllene on growth, as well as the antibacterial therapeutic effect, has been demonstrated. β-caryophyllene inhibited growth via the downregulation of E, N, B, and A and also downregulated virulence factors such as CagA, VacA, and SecA proteins. β-caryophyllene inhibited expression of several T4SS components, so that CagA translocation into -infected AGS gastric cancer cells was decreased by β-caryophyllene treatment. β-caryophyllene also inhibited VacA entry through the downregulation of T5SS. After β-caryophyllene administration on Mongolian gerbils, the immunohistochemistry (IHC) and Hematoxylin&Eosin stains showed therapeutic effects in the treated groups. Hematological data, which was consistent with histological data, support the therapeutic effect of β-caryophyllene administration. Such a positive effect of β-caryophyllene on infection potently substantiates the natural compound as being capable of being used as a new antimicrobial agent or functional health food to help patients who are suffering from gastroduodenal diseases due to infection.

摘要

人源特异性细菌病原体 () 与严重的胃部疾病相关，包括胃癌。最近，抗生素耐药性的增加使得抗生素的使用效果降低。因此，需要开发新的抗菌剂来控制 感染。在本研究中，已经证明了β-石竹烯对 的生长抑制作用以及抗菌治疗作用。β-石竹烯通过下调 E、N、B 和 A 来抑制 的生长，同时还下调了 CagA、VacA 和 SecA 等毒力因子。β-石竹烯抑制了几种 T4SS 成分的表达，从而使 CagA 易位到被 β-石竹烯处理的 -感染的 AGS 胃癌细胞减少。β-石竹烯还通过下调 T5SS 抑制 VacA 的进入。在蒙古沙土鼠中给予β-石竹烯后，免疫组织化学（IHC）和苏木精和伊红染色显示治疗组有治疗效果。与组织学数据一致的血液学数据支持β-石竹烯给药的治疗效果。β-石竹烯对 感染的这种积极影响有力地证实了天然化合物能够被用作新的抗菌剂或功能性保健品，以帮助因 感染而患有胃十二指肠疾病的患者。

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