School of Biological and Chemical Sciences, Birkbeck (University of London), Malet Street, London WC1E 7HX, UK.
Peptides. 2011 Mar;32(3):620-31. doi: 10.1016/j.peptides.2010.11.006. Epub 2010 Nov 18.
The nomenclature currently in use for insect neuropeptide and peptide hormone families is reviewed and suggestions are made as to how it can be rationalized. Based upon this review, a number of conventions are advanced as a guide to a more rationale nomenclature. The scheme that is put forward builds upon the binomial nomenclature scheme proposed by Raina and Gäde in 1988, when just over 20 insect neuropeptides had been identified. Known neuropeptides and peptide hormones are assigned to 32 structurally distinct families, frequently with overlapping functions. The names given to these families are those that are currently in use, and describe a biological function, homology to known invertebrate/vertebrate peptides, or a conserved structural motif. Interspecific isoforms are identified using a five-letter code to indicate genus and species names, and intraspecific isoforms are identified by Roman or Arabic numerals, with the latter used to signify the order in which sequences are encoded on a prepropeptide. The proposed scheme is sufficiently flexible to allow the incorporation of novel peptides, and could be extended to other arthropods and non-arthropod invertebrates.
目前用于昆虫神经肽和肽激素家族的命名法进行了回顾，并就如何使其合理化提出了建议。基于这一回顾，提出了一些惯例作为更合理命名法的指南。所提出的方案建立在 Raina 和 Gäde 于 1988 年提出的二项式命名方案的基础上，当时仅鉴定出超过 20 种昆虫神经肽。已知的神经肽和肽激素被分配到 32 个结构上不同的家族，这些家族通常具有重叠的功能。这些家族的名称是目前正在使用的名称，描述了生物学功能、与已知的无脊椎动物/脊椎动物肽的同源性，或保守的结构基序。种间同工型使用五个字母的代码来表示属和种名进行识别，种内同工型则使用罗马或阿拉伯数字进行识别，后者用于表示序列在一个前肽上编码的顺序。所提出的方案具有足够的灵活性，可以纳入新的肽，并且可以扩展到其他节肢动物和非节肢动物无脊椎动物。
